Teriflunomide shifts the astrocytic bioenergetic profile from oxidative metabolism to glycolysis and attenuates TNFα-induced inflammatory responses

Astrocytes utilize both glycolytic and mitochondrial pathways to power cellular processes that are vital to maintaining normal CNS functions. These cells also mount inflammatory and acute phase reactive programs in response to diverse stimuli. While the metabolic functions of astrocytes under homeos...

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Detalles Bibliográficos
Autores principales: Kabiraj, Parijat, Grund, Ethan M., Clarkson, Benjamin D. S., Johnson, Renee K., LaFrance-Corey, Reghann G., Lucchinetti, Claudia F., Howe, Charles L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866412/
https://www.ncbi.nlm.nih.gov/pubmed/35197552
http://dx.doi.org/10.1038/s41598-022-07024-7

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