Cargando…
Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission
Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness of travellers being required to quarantine for 14-days on return to England in Summer 2020. We identified 4,207 travel-related SARS-CoV-2 cases and their contacts, and identified 827 associa...
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866425/ https://www.ncbi.nlm.nih.gov/pubmed/35197443 http://dx.doi.org/10.1038/s41467-022-28371-z |
| _version_ | 1784655834430570496 |
|---|---|
| author | Aggarwal, Dinesh Page, Andrew J. Schaefer, Ulf Savva, George M. Myers, Richard Volz, Erik Ellaby, Nicholas Platt, Steven Groves, Natalie Gallagher, Eileen Tumelty, Niamh M. Le Viet, Thanh Hughes, Gareth J. Chen, Cong Turner, Charlie Logan, Sophie Harrison, Abbie Peacock, Sharon J. Chand, Meera Harrison, Ewan M. |
| author_facet | Aggarwal, Dinesh Page, Andrew J. Schaefer, Ulf Savva, George M. Myers, Richard Volz, Erik Ellaby, Nicholas Platt, Steven Groves, Natalie Gallagher, Eileen Tumelty, Niamh M. Le Viet, Thanh Hughes, Gareth J. Chen, Cong Turner, Charlie Logan, Sophie Harrison, Abbie Peacock, Sharon J. Chand, Meera Harrison, Ewan M. |
| author_sort | Aggarwal, Dinesh |
| collection | PubMed |
| description | Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness of travellers being required to quarantine for 14-days on return to England in Summer 2020. We identified 4,207 travel-related SARS-CoV-2 cases and their contacts, and identified 827 associated SARS-CoV-2 genomes. Overall, quarantine was associated with a lower rate of contacts, and the impact of quarantine was greatest in the 16–20 age-group. 186 SARS-CoV-2 genomes were sufficiently unique to identify travel-related clusters. Fewer genomically-linked cases were observed for index cases who returned from countries with quarantine requirement compared to countries with no quarantine requirement. This difference was explained by fewer importation events per identified genome for these cases, as opposed to fewer onward contacts per case. Overall, our study demonstrates that a 14-day quarantine period reduces, but does not completely eliminate, the onward transmission of imported cases, mainly by dissuading travel to countries with a quarantine requirement. |
| format | Online Article Text |
| id | pubmed-8866425 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-88664252022-03-17 Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission Aggarwal, Dinesh Page, Andrew J. Schaefer, Ulf Savva, George M. Myers, Richard Volz, Erik Ellaby, Nicholas Platt, Steven Groves, Natalie Gallagher, Eileen Tumelty, Niamh M. Le Viet, Thanh Hughes, Gareth J. Chen, Cong Turner, Charlie Logan, Sophie Harrison, Abbie Peacock, Sharon J. Chand, Meera Harrison, Ewan M. Nat Commun Article Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness of travellers being required to quarantine for 14-days on return to England in Summer 2020. We identified 4,207 travel-related SARS-CoV-2 cases and their contacts, and identified 827 associated SARS-CoV-2 genomes. Overall, quarantine was associated with a lower rate of contacts, and the impact of quarantine was greatest in the 16–20 age-group. 186 SARS-CoV-2 genomes were sufficiently unique to identify travel-related clusters. Fewer genomically-linked cases were observed for index cases who returned from countries with quarantine requirement compared to countries with no quarantine requirement. This difference was explained by fewer importation events per identified genome for these cases, as opposed to fewer onward contacts per case. Overall, our study demonstrates that a 14-day quarantine period reduces, but does not completely eliminate, the onward transmission of imported cases, mainly by dissuading travel to countries with a quarantine requirement. Nature Publishing Group UK 2022-02-23 /pmc/articles/PMC8866425/ /pubmed/35197443 http://dx.doi.org/10.1038/s41467-022-28371-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Aggarwal, Dinesh Page, Andrew J. Schaefer, Ulf Savva, George M. Myers, Richard Volz, Erik Ellaby, Nicholas Platt, Steven Groves, Natalie Gallagher, Eileen Tumelty, Niamh M. Le Viet, Thanh Hughes, Gareth J. Chen, Cong Turner, Charlie Logan, Sophie Harrison, Abbie Peacock, Sharon J. Chand, Meera Harrison, Ewan M. Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission |
| title | Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission |
| title_full | Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission |
| title_fullStr | Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission |
| title_full_unstemmed | Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission |
| title_short | Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission |
| title_sort | genomic assessment of quarantine measures to prevent sars-cov-2 importation and transmission |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866425/ https://www.ncbi.nlm.nih.gov/pubmed/35197443 http://dx.doi.org/10.1038/s41467-022-28371-z |
| work_keys_str_mv | AT aggarwaldinesh genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT pageandrewj genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT schaeferulf genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT savvageorgem genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT myersrichard genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT volzerik genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT ellabynicholas genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT plattsteven genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT grovesnatalie genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT gallaghereileen genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT tumeltyniamhm genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT levietthanh genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT hughesgarethj genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT chencong genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT turnercharlie genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT logansophie genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT harrisonabbie genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT peacocksharonj genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT chandmeera genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission AT harrisonewanm genomicassessmentofquarantinemeasurestopreventsarscov2importationandtransmission |