Small Cajal body-associated RNA 2 (scaRNA2) regulates DNA repair pathway choice by inhibiting DNA-PK

Evidence that long non-coding RNAs (lncRNAs) participate in DNA repair is accumulating, however, whether they can control DNA repair pathway choice is unknown. Here we show that the small Cajal body-specific RNA 2 (scaRNA2) can promote HR by inhibiting DNA-dependent protein kinase (DNA-PK) and, ther...

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Detalles Bibliográficos
Autores principales: Bergstrand, Sofie, O’Brien, Eleanor M., Coucoravas, Christos, Hrossova, Dominika, Peirasmaki, Dimitra, Schmidli, Sandro, Dhanjal, Soniya, Pederiva, Chiara, Siggens, Lee, Mortusewicz, Oliver, O’Rourke, Julienne J., Farnebo, Marianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866460/
https://www.ncbi.nlm.nih.gov/pubmed/35197472
http://dx.doi.org/10.1038/s41467-022-28646-5

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