Internalization and trafficking of CSPG-bound recombinant VAR2CSA lectins in cancer cells

Proteoglycans are proteins that are modified with glycosaminoglycan chains. Chondroitin sulfate proteoglycans (CSPGs) are currently being exploited as targets for drug-delivery in various cancer indications, however basic knowledge on how CSPGs are internalized in tumor cells is lacking. In this stu...

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Detalles Bibliográficos
Autores principales: Wang, Chris Kedong, Nelepcu, Irina, Hui, Desmond, Oo, Htoo Zarni, Truong, Sarah, Zhao, Sarah, Tahiry, Zakir, Esfandnia, Shaghayegh, Ghaidi, Fariba, Adomat, Hans, Dagil, Robert, Gustavsson, Tobias, Choudhary, Swati, Salanti, Ali, Sorensen, Poul H., Al Nakouzi, Nader, Daugaard, Mads
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866492/
https://www.ncbi.nlm.nih.gov/pubmed/35197518
http://dx.doi.org/10.1038/s41598-022-07025-6

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