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Metabolomic response to collegiate football participation: Pre- and Post-season analysis

Contact sports participation has been shown to have both beneficial and detrimental effects on health, however little is known about the metabolic sequelae of these effects. We aimed to identify metabolite alterations across a collegiate American football season. Serum was collected from 23 male col...

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Autores principales: Vike, Nicole L., Bari, Sumra, Stetsiv, Khrystyna, Talavage, Thomas M., Nauman, Eric A., Papa, Linda, Slobounov, Semyon, Breiter, Hans C., Cornelis, Marilyn C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866500/
https://www.ncbi.nlm.nih.gov/pubmed/35197541
http://dx.doi.org/10.1038/s41598-022-07079-6
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author Vike, Nicole L.
Bari, Sumra
Stetsiv, Khrystyna
Talavage, Thomas M.
Nauman, Eric A.
Papa, Linda
Slobounov, Semyon
Breiter, Hans C.
Cornelis, Marilyn C.
author_facet Vike, Nicole L.
Bari, Sumra
Stetsiv, Khrystyna
Talavage, Thomas M.
Nauman, Eric A.
Papa, Linda
Slobounov, Semyon
Breiter, Hans C.
Cornelis, Marilyn C.
author_sort Vike, Nicole L.
collection PubMed
description Contact sports participation has been shown to have both beneficial and detrimental effects on health, however little is known about the metabolic sequelae of these effects. We aimed to identify metabolite alterations across a collegiate American football season. Serum was collected from 23 male collegiate football athletes before the athletic season (Pre) and after the last game (Post). Samples underwent nontargeted metabolomic profiling and 1131 metabolites were included for univariate, pathway enrichment, and multivariate analyses. Significant metabolites were assessed against head acceleration events (HAEs). 200 metabolites changed from Pre to Post (P < 0.05 and Q < 0.05); 160 had known identity and mapped to one of 57 pre-defined biological pathways. There was significant enrichment of metabolites belonging to five pathways (P < 0.05): xanthine, fatty acid (acyl choline), medium chain fatty acid, primary bile acid, and glycolysis, gluconeogenesis, and pyruvate metabolism. A set of 12 metabolites was sufficient to discriminate Pre from Post status, and changes in 64 of the 200 metabolites were also associated with HAEs (P < 0.05). In summary, the identified metabolites, and candidate pathways, argue there are metabolic consequences of both physical training and head impacts with football participation. These findings additionally identify a potential set of objective biomarkers of repetitive head injury.
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spelling pubmed-88665002022-02-25 Metabolomic response to collegiate football participation: Pre- and Post-season analysis Vike, Nicole L. Bari, Sumra Stetsiv, Khrystyna Talavage, Thomas M. Nauman, Eric A. Papa, Linda Slobounov, Semyon Breiter, Hans C. Cornelis, Marilyn C. Sci Rep Article Contact sports participation has been shown to have both beneficial and detrimental effects on health, however little is known about the metabolic sequelae of these effects. We aimed to identify metabolite alterations across a collegiate American football season. Serum was collected from 23 male collegiate football athletes before the athletic season (Pre) and after the last game (Post). Samples underwent nontargeted metabolomic profiling and 1131 metabolites were included for univariate, pathway enrichment, and multivariate analyses. Significant metabolites were assessed against head acceleration events (HAEs). 200 metabolites changed from Pre to Post (P < 0.05 and Q < 0.05); 160 had known identity and mapped to one of 57 pre-defined biological pathways. There was significant enrichment of metabolites belonging to five pathways (P < 0.05): xanthine, fatty acid (acyl choline), medium chain fatty acid, primary bile acid, and glycolysis, gluconeogenesis, and pyruvate metabolism. A set of 12 metabolites was sufficient to discriminate Pre from Post status, and changes in 64 of the 200 metabolites were also associated with HAEs (P < 0.05). In summary, the identified metabolites, and candidate pathways, argue there are metabolic consequences of both physical training and head impacts with football participation. These findings additionally identify a potential set of objective biomarkers of repetitive head injury. Nature Publishing Group UK 2022-02-23 /pmc/articles/PMC8866500/ /pubmed/35197541 http://dx.doi.org/10.1038/s41598-022-07079-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Vike, Nicole L.
Bari, Sumra
Stetsiv, Khrystyna
Talavage, Thomas M.
Nauman, Eric A.
Papa, Linda
Slobounov, Semyon
Breiter, Hans C.
Cornelis, Marilyn C.
Metabolomic response to collegiate football participation: Pre- and Post-season analysis
title Metabolomic response to collegiate football participation: Pre- and Post-season analysis
title_full Metabolomic response to collegiate football participation: Pre- and Post-season analysis
title_fullStr Metabolomic response to collegiate football participation: Pre- and Post-season analysis
title_full_unstemmed Metabolomic response to collegiate football participation: Pre- and Post-season analysis
title_short Metabolomic response to collegiate football participation: Pre- and Post-season analysis
title_sort metabolomic response to collegiate football participation: pre- and post-season analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866500/
https://www.ncbi.nlm.nih.gov/pubmed/35197541
http://dx.doi.org/10.1038/s41598-022-07079-6
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