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Neuroprotective effect of Mulmina Mango against chemotherapy-induced cognitive decline in mouse model of mammary carcinoma

The post-treatment status of breast cancer survivors has become a concern because of the toxicity induced by chemotherapeutic agents in the brain tissues resulting in cognitive deficits, which is generally referred as chemobrain. The aim of this study was to assess the effect of a proprietary ayurve...

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Autores principales: John, Jeena, Kinra, Manas, Ranadive, Niraja, Keni, Raghuvir, Nayak, Pawan Ganesh, Jagdale, Rajesh N., Ahmed, Syed M., Raghavendra, Kaggundi V., Mudgal, Jayesh, Nandakumar, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866531/
https://www.ncbi.nlm.nih.gov/pubmed/35197512
http://dx.doi.org/10.1038/s41598-022-06862-9
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author John, Jeena
Kinra, Manas
Ranadive, Niraja
Keni, Raghuvir
Nayak, Pawan Ganesh
Jagdale, Rajesh N.
Ahmed, Syed M.
Raghavendra, Kaggundi V.
Mudgal, Jayesh
Nandakumar, K.
author_facet John, Jeena
Kinra, Manas
Ranadive, Niraja
Keni, Raghuvir
Nayak, Pawan Ganesh
Jagdale, Rajesh N.
Ahmed, Syed M.
Raghavendra, Kaggundi V.
Mudgal, Jayesh
Nandakumar, K.
author_sort John, Jeena
collection PubMed
description The post-treatment status of breast cancer survivors has become a concern because of the toxicity induced by chemotherapeutic agents in the brain tissues resulting in cognitive deficits, which is generally referred as chemobrain. The aim of this study was to assess the effect of a proprietary ayurvedic formulation Mulmina Mango against chemotherapy-induced cognitive impairment (CICI). Mammary carcinoma was induced by subcutaneously inoculating 4T1 cells into the mammary fat pad of the animals. Intraperitoneal administration of Cyclophosphamide, Methotrexate, 5-Fluorouracil (CMF) regimen was carried out once a week for three weeks. Treatment of Mulmina began one week before chemotherapy and continued till the end of the chemotherapy cycle. After three cycles of chemotherapy, cognitive decline was assessed by Morris water maze task followed by assessment of locomotor activity by open-field test. Tumor progression was evaluated by measurement of tumor volume. Oxidative and neuroinflammatory markers were also evaluated from the isolated brain samples. CMF treatment resulted in a considerable reduction in tumour volume. We found chemotherapy negatively affected behavioral and biochemical parameters in animals and Mulmina treatment ameliorated these cognitive impairments by restoring antioxidant and maintaining cytokine levels. The combination of phytochemicals in Mulmina proved its possible ability to alleviate CICI without affecting chemotherapeutic efficiency and could pave the way for identifying treatment strategies to combat chemobrain.
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spelling pubmed-88665312022-02-25 Neuroprotective effect of Mulmina Mango against chemotherapy-induced cognitive decline in mouse model of mammary carcinoma John, Jeena Kinra, Manas Ranadive, Niraja Keni, Raghuvir Nayak, Pawan Ganesh Jagdale, Rajesh N. Ahmed, Syed M. Raghavendra, Kaggundi V. Mudgal, Jayesh Nandakumar, K. Sci Rep Article The post-treatment status of breast cancer survivors has become a concern because of the toxicity induced by chemotherapeutic agents in the brain tissues resulting in cognitive deficits, which is generally referred as chemobrain. The aim of this study was to assess the effect of a proprietary ayurvedic formulation Mulmina Mango against chemotherapy-induced cognitive impairment (CICI). Mammary carcinoma was induced by subcutaneously inoculating 4T1 cells into the mammary fat pad of the animals. Intraperitoneal administration of Cyclophosphamide, Methotrexate, 5-Fluorouracil (CMF) regimen was carried out once a week for three weeks. Treatment of Mulmina began one week before chemotherapy and continued till the end of the chemotherapy cycle. After three cycles of chemotherapy, cognitive decline was assessed by Morris water maze task followed by assessment of locomotor activity by open-field test. Tumor progression was evaluated by measurement of tumor volume. Oxidative and neuroinflammatory markers were also evaluated from the isolated brain samples. CMF treatment resulted in a considerable reduction in tumour volume. We found chemotherapy negatively affected behavioral and biochemical parameters in animals and Mulmina treatment ameliorated these cognitive impairments by restoring antioxidant and maintaining cytokine levels. The combination of phytochemicals in Mulmina proved its possible ability to alleviate CICI without affecting chemotherapeutic efficiency and could pave the way for identifying treatment strategies to combat chemobrain. Nature Publishing Group UK 2022-02-23 /pmc/articles/PMC8866531/ /pubmed/35197512 http://dx.doi.org/10.1038/s41598-022-06862-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
John, Jeena
Kinra, Manas
Ranadive, Niraja
Keni, Raghuvir
Nayak, Pawan Ganesh
Jagdale, Rajesh N.
Ahmed, Syed M.
Raghavendra, Kaggundi V.
Mudgal, Jayesh
Nandakumar, K.
Neuroprotective effect of Mulmina Mango against chemotherapy-induced cognitive decline in mouse model of mammary carcinoma
title Neuroprotective effect of Mulmina Mango against chemotherapy-induced cognitive decline in mouse model of mammary carcinoma
title_full Neuroprotective effect of Mulmina Mango against chemotherapy-induced cognitive decline in mouse model of mammary carcinoma
title_fullStr Neuroprotective effect of Mulmina Mango against chemotherapy-induced cognitive decline in mouse model of mammary carcinoma
title_full_unstemmed Neuroprotective effect of Mulmina Mango against chemotherapy-induced cognitive decline in mouse model of mammary carcinoma
title_short Neuroprotective effect of Mulmina Mango against chemotherapy-induced cognitive decline in mouse model of mammary carcinoma
title_sort neuroprotective effect of mulmina mango against chemotherapy-induced cognitive decline in mouse model of mammary carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866531/
https://www.ncbi.nlm.nih.gov/pubmed/35197512
http://dx.doi.org/10.1038/s41598-022-06862-9
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