Three new pyrrole alkaloids from the endophytic fungus Albifimbria viridis

Three new pyrrole alkaloids albifipyrrols A–C (1–3), were isolated from the endophytic fungus Albifimbria viridis collected from the Chinese medicinal plant. Their structures were elucidated by extensive NMR and HRESIMS spectrometric analyses. All compounds were evaluated for immunosuppressive activ...

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Autores principales: Wei, Pan-Pan, Ji, Jia-Cheng, Ma, Xu-Jun, Li, Zheng-Hui, Ai, Hong-Lian, Lei, Xin-Xiang, Liu, Ji-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866607/
https://www.ncbi.nlm.nih.gov/pubmed/35199234
http://dx.doi.org/10.1007/s13659-022-00327-2
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author Wei, Pan-Pan
Ji, Jia-Cheng
Ma, Xu-Jun
Li, Zheng-Hui
Ai, Hong-Lian
Lei, Xin-Xiang
Liu, Ji-Kai
author_facet Wei, Pan-Pan
Ji, Jia-Cheng
Ma, Xu-Jun
Li, Zheng-Hui
Ai, Hong-Lian
Lei, Xin-Xiang
Liu, Ji-Kai
author_sort Wei, Pan-Pan
collection PubMed
description Three new pyrrole alkaloids albifipyrrols A–C (1–3), were isolated from the endophytic fungus Albifimbria viridis collected from the Chinese medicinal plant. Their structures were elucidated by extensive NMR and HRESIMS spectrometric analyses. All compounds were evaluated for immunosuppressive activity. Fortunately, compound 2 exhibits certain inhibition specifically against the LPS-induced proliferation of B lymphocyte cells with IC(50) value 16.16 μM. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-022-00327-2.
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spelling pubmed-88666072022-03-02 Three new pyrrole alkaloids from the endophytic fungus Albifimbria viridis Wei, Pan-Pan Ji, Jia-Cheng Ma, Xu-Jun Li, Zheng-Hui Ai, Hong-Lian Lei, Xin-Xiang Liu, Ji-Kai Nat Prod Bioprospect Original Article Three new pyrrole alkaloids albifipyrrols A–C (1–3), were isolated from the endophytic fungus Albifimbria viridis collected from the Chinese medicinal plant. Their structures were elucidated by extensive NMR and HRESIMS spectrometric analyses. All compounds were evaluated for immunosuppressive activity. Fortunately, compound 2 exhibits certain inhibition specifically against the LPS-induced proliferation of B lymphocyte cells with IC(50) value 16.16 μM. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-022-00327-2. Springer Singapore 2022-02-24 /pmc/articles/PMC8866607/ /pubmed/35199234 http://dx.doi.org/10.1007/s13659-022-00327-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Wei, Pan-Pan
Ji, Jia-Cheng
Ma, Xu-Jun
Li, Zheng-Hui
Ai, Hong-Lian
Lei, Xin-Xiang
Liu, Ji-Kai
Three new pyrrole alkaloids from the endophytic fungus Albifimbria viridis
title Three new pyrrole alkaloids from the endophytic fungus Albifimbria viridis
title_full Three new pyrrole alkaloids from the endophytic fungus Albifimbria viridis
title_fullStr Three new pyrrole alkaloids from the endophytic fungus Albifimbria viridis
title_full_unstemmed Three new pyrrole alkaloids from the endophytic fungus Albifimbria viridis
title_short Three new pyrrole alkaloids from the endophytic fungus Albifimbria viridis
title_sort three new pyrrole alkaloids from the endophytic fungus albifimbria viridis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866607/
https://www.ncbi.nlm.nih.gov/pubmed/35199234
http://dx.doi.org/10.1007/s13659-022-00327-2
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