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Organ-On-A-Chip: A Survey of Technical Results and Problems

Organ-on-a-chip (OoC), also known as micro physiological systems or “tissue chips” have attracted substantial interest in recent years due to their numerous applications, especially in precision medicine, drug development and screening. Organ-on-a-chip devices can replicate key aspects of human phys...

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Autores principales: Danku, Alex Ede, Dulf, Eva-H, Braicu, Cornelia, Jurj, Ancuta, Berindan-Neagoe, Ioana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866728/
https://www.ncbi.nlm.nih.gov/pubmed/35223800
http://dx.doi.org/10.3389/fbioe.2022.840674
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author Danku, Alex Ede
Dulf, Eva-H
Braicu, Cornelia
Jurj, Ancuta
Berindan-Neagoe, Ioana
author_facet Danku, Alex Ede
Dulf, Eva-H
Braicu, Cornelia
Jurj, Ancuta
Berindan-Neagoe, Ioana
author_sort Danku, Alex Ede
collection PubMed
description Organ-on-a-chip (OoC), also known as micro physiological systems or “tissue chips” have attracted substantial interest in recent years due to their numerous applications, especially in precision medicine, drug development and screening. Organ-on-a-chip devices can replicate key aspects of human physiology, providing insights into the studied organ function and disease pathophysiology. Moreover, these can accurately be used in drug discovery for personalized medicine. These devices present useful substitutes to traditional preclinical cell culture methods and can reduce the use of in vivo animal studies. In the last few years OoC design technology has seen dramatic advances, leading to a wide range of biomedical applications. These advances have also revealed not only new challenges but also new opportunities. There is a need for multidisciplinary knowledge from the biomedical and engineering fields to understand and realize OoCs. The present review provides a snapshot of this fast-evolving technology, discusses current applications and highlights advantages and disadvantages for biomedical approaches.
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spelling pubmed-88667282022-02-25 Organ-On-A-Chip: A Survey of Technical Results and Problems Danku, Alex Ede Dulf, Eva-H Braicu, Cornelia Jurj, Ancuta Berindan-Neagoe, Ioana Front Bioeng Biotechnol Bioengineering and Biotechnology Organ-on-a-chip (OoC), also known as micro physiological systems or “tissue chips” have attracted substantial interest in recent years due to their numerous applications, especially in precision medicine, drug development and screening. Organ-on-a-chip devices can replicate key aspects of human physiology, providing insights into the studied organ function and disease pathophysiology. Moreover, these can accurately be used in drug discovery for personalized medicine. These devices present useful substitutes to traditional preclinical cell culture methods and can reduce the use of in vivo animal studies. In the last few years OoC design technology has seen dramatic advances, leading to a wide range of biomedical applications. These advances have also revealed not only new challenges but also new opportunities. There is a need for multidisciplinary knowledge from the biomedical and engineering fields to understand and realize OoCs. The present review provides a snapshot of this fast-evolving technology, discusses current applications and highlights advantages and disadvantages for biomedical approaches. Frontiers Media S.A. 2022-02-10 /pmc/articles/PMC8866728/ /pubmed/35223800 http://dx.doi.org/10.3389/fbioe.2022.840674 Text en Copyright © 2022 Danku, Dulf, Braicu, Jurj and Berindan-Neagoe. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Danku, Alex Ede
Dulf, Eva-H
Braicu, Cornelia
Jurj, Ancuta
Berindan-Neagoe, Ioana
Organ-On-A-Chip: A Survey of Technical Results and Problems
title Organ-On-A-Chip: A Survey of Technical Results and Problems
title_full Organ-On-A-Chip: A Survey of Technical Results and Problems
title_fullStr Organ-On-A-Chip: A Survey of Technical Results and Problems
title_full_unstemmed Organ-On-A-Chip: A Survey of Technical Results and Problems
title_short Organ-On-A-Chip: A Survey of Technical Results and Problems
title_sort organ-on-a-chip: a survey of technical results and problems
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866728/
https://www.ncbi.nlm.nih.gov/pubmed/35223800
http://dx.doi.org/10.3389/fbioe.2022.840674
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