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Quantification of dissolved H(2) and continuous monitoring of hydrogen-rich water for haemodialysis applications: An experimental study
The prevalence of oxidative and inflammatory stress in end-stage renal disease (ESRD) patients has often been associated with chronic haemodialysis therapies. Over the past decades, several reports have shown the potential of hydrogen molecule as an antioxidant in the treatment of various medical co...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866747/ https://www.ncbi.nlm.nih.gov/pubmed/35075943 http://dx.doi.org/10.1177/03913988211070588 |
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author | Mouzakis, Foivos Leonidas Khadka, Lal Babu Pereira da Silva, Miguel Mottaghy, Khosrow |
author_facet | Mouzakis, Foivos Leonidas Khadka, Lal Babu Pereira da Silva, Miguel Mottaghy, Khosrow |
author_sort | Mouzakis, Foivos Leonidas |
collection | PubMed |
description | The prevalence of oxidative and inflammatory stress in end-stage renal disease (ESRD) patients has often been associated with chronic haemodialysis therapies. Over the past decades, several reports have shown the potential of hydrogen molecule as an antioxidant in the treatment of various medical conditions in animal models, as well as in pilot studies with human patients. Recently, a hydrogen-enriched dialysate solution has been introduced, holding promise in reducing the oxidative and/or inflammatory complications arising during haemodialysis. To this end, a standardised measuring method to determine the levels of hydrogen in dialysate and subsequently in blood is required. This study explores the possibility of quantifying hydrogen concentration using a novel contactless sensor that detects dissolved hydrogen in liquids. An experimental circuit is assembled to validate the sensitivity and accuracy of the hydrogen monitoring system (Pureron Japan Co., Ltd) through in vitro investigations with physiological solutions. Measurements of dissolved molecular hydrogen concentration are corroborated by an established oxygen sensor providing continuous partial pressure readings. The relationship between the applied H(2) content in the gaseous mixture and the H(2) concentration value at equilibrium is linear. At the same time, the hydrogen monitoring system has a rather long response time, and its readings seem to slightly diverge from sensor to sensor as well as at different temperatures. For this reason, a sensor recalibration might be necessary, which could become part of the product’s ongoing development. Nevertheless, the aforementioned minor deficiencies can be mostly considered negligible in applications such as haemodialysis. |
format | Online Article Text |
id | pubmed-8866747 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-88667472022-02-25 Quantification of dissolved H(2) and continuous monitoring of hydrogen-rich water for haemodialysis applications: An experimental study Mouzakis, Foivos Leonidas Khadka, Lal Babu Pereira da Silva, Miguel Mottaghy, Khosrow Int J Artif Organs Original Research Articles The prevalence of oxidative and inflammatory stress in end-stage renal disease (ESRD) patients has often been associated with chronic haemodialysis therapies. Over the past decades, several reports have shown the potential of hydrogen molecule as an antioxidant in the treatment of various medical conditions in animal models, as well as in pilot studies with human patients. Recently, a hydrogen-enriched dialysate solution has been introduced, holding promise in reducing the oxidative and/or inflammatory complications arising during haemodialysis. To this end, a standardised measuring method to determine the levels of hydrogen in dialysate and subsequently in blood is required. This study explores the possibility of quantifying hydrogen concentration using a novel contactless sensor that detects dissolved hydrogen in liquids. An experimental circuit is assembled to validate the sensitivity and accuracy of the hydrogen monitoring system (Pureron Japan Co., Ltd) through in vitro investigations with physiological solutions. Measurements of dissolved molecular hydrogen concentration are corroborated by an established oxygen sensor providing continuous partial pressure readings. The relationship between the applied H(2) content in the gaseous mixture and the H(2) concentration value at equilibrium is linear. At the same time, the hydrogen monitoring system has a rather long response time, and its readings seem to slightly diverge from sensor to sensor as well as at different temperatures. For this reason, a sensor recalibration might be necessary, which could become part of the product’s ongoing development. Nevertheless, the aforementioned minor deficiencies can be mostly considered negligible in applications such as haemodialysis. SAGE Publications 2022-01-25 2022-03 /pmc/articles/PMC8866747/ /pubmed/35075943 http://dx.doi.org/10.1177/03913988211070588 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Articles Mouzakis, Foivos Leonidas Khadka, Lal Babu Pereira da Silva, Miguel Mottaghy, Khosrow Quantification of dissolved H(2) and continuous monitoring of hydrogen-rich water for haemodialysis applications: An experimental study |
title | Quantification of dissolved H(2) and continuous monitoring
of hydrogen-rich water for haemodialysis applications: An experimental
study |
title_full | Quantification of dissolved H(2) and continuous monitoring
of hydrogen-rich water for haemodialysis applications: An experimental
study |
title_fullStr | Quantification of dissolved H(2) and continuous monitoring
of hydrogen-rich water for haemodialysis applications: An experimental
study |
title_full_unstemmed | Quantification of dissolved H(2) and continuous monitoring
of hydrogen-rich water for haemodialysis applications: An experimental
study |
title_short | Quantification of dissolved H(2) and continuous monitoring
of hydrogen-rich water for haemodialysis applications: An experimental
study |
title_sort | quantification of dissolved h(2) and continuous monitoring
of hydrogen-rich water for haemodialysis applications: an experimental
study |
topic | Original Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866747/ https://www.ncbi.nlm.nih.gov/pubmed/35075943 http://dx.doi.org/10.1177/03913988211070588 |
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