Epstein-Barr Virus-positive Intestinal Diffuse Large B-cell Lymphoma in a Japanese Patient with Celiac Disease: First Reported Case and a Literature Review

A 60-year-old Japanese woman was diagnosed with celiac disease (CeD) and treated with a gluten-free diet. For five years, she had a good clinical course. However, she complained of inappetence and nausea. Colonoscopy revealed ulcerative tumors in the terminal ileum. A histological examination of bio...

Descripción completa

Detalles Bibliográficos
Autores principales: Ishibashi, Hideki, Imakiire, So, Goto, Maki, Nomaru, Ryohei, Shibata, Mamoru, Matsuoka, Hiroki, Yasuda, Hideki, Yamashima, Tomomi, Sakisaka, Hideto, Tanabe, Taro, Matsuoka, Satoshi, Kuno, Nobuaki, Abe, Koichi, Funakoshi, Sadahiro, Takamatsu, Yasushi, Hirai, Fumihito, Takeshita, Morishige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866777/
https://www.ncbi.nlm.nih.gov/pubmed/34334570
http://dx.doi.org/10.2169/internalmedicine.7876-21
Descripción
Sumario:A 60-year-old Japanese woman was diagnosed with celiac disease (CeD) and treated with a gluten-free diet. For five years, she had a good clinical course. However, she complained of inappetence and nausea. Colonoscopy revealed ulcerative tumors in the terminal ileum. A histological examination of biopsy specimens from the ulcerative tumor showed diffuse infiltration of large atypical lymphocytes. Immunohistologically, the atypical lymphoid cells were positive for cluster of differentiation (CD)10 and CD20. Many Epstein-Barr virus-encoded small RNA (EBER)-positive atypical lymphocytes were detected by in situ hybridization. This represents the first reported case of Epstein-Barr virus-positive intestinal diffuse large B-cell lymphoma complicated with CeD.

Ejemplares similares