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Semantic Integration of Multi-Modal Data and Derived Neuroimaging Results Using the Platform for Imaging in Precision Medicine (PRISM) in the Arkansas Imaging Enterprise System (ARIES)

Neuroimaging is among the most active research domains for the creation and management of open-access data repositories. Notably lacking from most data repositories are integrated capabilities for semantic representation. The Arkansas Imaging Enterprise System (ARIES) is a research data management s...

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Autores principales: Bona, Jonathan, Kemp, Aaron S., Cox, Carli, Nolan, Tracy S., Pillai, Lakshmi, Das, Aparna, Galvin, James E., Larson-Prior, Linda, Virmani, Tuhin, Prior, Fred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866818/
https://www.ncbi.nlm.nih.gov/pubmed/35224477
http://dx.doi.org/10.3389/frai.2021.649970
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author Bona, Jonathan
Kemp, Aaron S.
Cox, Carli
Nolan, Tracy S.
Pillai, Lakshmi
Das, Aparna
Galvin, James E.
Larson-Prior, Linda
Virmani, Tuhin
Prior, Fred
author_facet Bona, Jonathan
Kemp, Aaron S.
Cox, Carli
Nolan, Tracy S.
Pillai, Lakshmi
Das, Aparna
Galvin, James E.
Larson-Prior, Linda
Virmani, Tuhin
Prior, Fred
author_sort Bona, Jonathan
collection PubMed
description Neuroimaging is among the most active research domains for the creation and management of open-access data repositories. Notably lacking from most data repositories are integrated capabilities for semantic representation. The Arkansas Imaging Enterprise System (ARIES) is a research data management system which features integrated capabilities to support semantic representations of multi-modal data from disparate sources (imaging, behavioral, or cognitive assessments), across common image-processing stages (preprocessing steps, segmentation schemes, analytic pipelines), as well as derived results (publishable findings). These unique capabilities ensure greater reproducibility of scientific findings across large-scale research projects. The current investigation was conducted with three collaborating teams who are using ARIES in a project focusing on neurodegeneration. Datasets included magnetic resonance imaging (MRI) data as well as non-imaging data obtained from a variety of assessments designed to measure neurocognitive functions (performance scores on neuropsychological tests). We integrate and manage these data with semantic representations based on axiomatically rich biomedical ontologies. These instantiate a knowledge graph that combines the data from the study cohorts into a shared semantic representation that explicitly accounts for relations among the entities that the data are about. This knowledge graph is stored in a triple-store database that supports reasoning over and querying these integrated data. Semantic integration of the non-imaging data using background information encoded in biomedical domain ontologies has served as a key feature-engineering step, allowing us to combine disparate data and apply analyses to explore associations, for instance, between hippocampal volumes and measures of cognitive functions derived from various assessment instruments.
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spelling pubmed-88668182022-02-25 Semantic Integration of Multi-Modal Data and Derived Neuroimaging Results Using the Platform for Imaging in Precision Medicine (PRISM) in the Arkansas Imaging Enterprise System (ARIES) Bona, Jonathan Kemp, Aaron S. Cox, Carli Nolan, Tracy S. Pillai, Lakshmi Das, Aparna Galvin, James E. Larson-Prior, Linda Virmani, Tuhin Prior, Fred Front Artif Intell Artificial Intelligence Neuroimaging is among the most active research domains for the creation and management of open-access data repositories. Notably lacking from most data repositories are integrated capabilities for semantic representation. The Arkansas Imaging Enterprise System (ARIES) is a research data management system which features integrated capabilities to support semantic representations of multi-modal data from disparate sources (imaging, behavioral, or cognitive assessments), across common image-processing stages (preprocessing steps, segmentation schemes, analytic pipelines), as well as derived results (publishable findings). These unique capabilities ensure greater reproducibility of scientific findings across large-scale research projects. The current investigation was conducted with three collaborating teams who are using ARIES in a project focusing on neurodegeneration. Datasets included magnetic resonance imaging (MRI) data as well as non-imaging data obtained from a variety of assessments designed to measure neurocognitive functions (performance scores on neuropsychological tests). We integrate and manage these data with semantic representations based on axiomatically rich biomedical ontologies. These instantiate a knowledge graph that combines the data from the study cohorts into a shared semantic representation that explicitly accounts for relations among the entities that the data are about. This knowledge graph is stored in a triple-store database that supports reasoning over and querying these integrated data. Semantic integration of the non-imaging data using background information encoded in biomedical domain ontologies has served as a key feature-engineering step, allowing us to combine disparate data and apply analyses to explore associations, for instance, between hippocampal volumes and measures of cognitive functions derived from various assessment instruments. Frontiers Media S.A. 2022-02-10 /pmc/articles/PMC8866818/ /pubmed/35224477 http://dx.doi.org/10.3389/frai.2021.649970 Text en Copyright © 2022 Bona, Kemp, Cox, Nolan, Pillai, Das, Galvin, Larson-Prior, Virmani and Prior. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Artificial Intelligence
Bona, Jonathan
Kemp, Aaron S.
Cox, Carli
Nolan, Tracy S.
Pillai, Lakshmi
Das, Aparna
Galvin, James E.
Larson-Prior, Linda
Virmani, Tuhin
Prior, Fred
Semantic Integration of Multi-Modal Data and Derived Neuroimaging Results Using the Platform for Imaging in Precision Medicine (PRISM) in the Arkansas Imaging Enterprise System (ARIES)
title Semantic Integration of Multi-Modal Data and Derived Neuroimaging Results Using the Platform for Imaging in Precision Medicine (PRISM) in the Arkansas Imaging Enterprise System (ARIES)
title_full Semantic Integration of Multi-Modal Data and Derived Neuroimaging Results Using the Platform for Imaging in Precision Medicine (PRISM) in the Arkansas Imaging Enterprise System (ARIES)
title_fullStr Semantic Integration of Multi-Modal Data and Derived Neuroimaging Results Using the Platform for Imaging in Precision Medicine (PRISM) in the Arkansas Imaging Enterprise System (ARIES)
title_full_unstemmed Semantic Integration of Multi-Modal Data and Derived Neuroimaging Results Using the Platform for Imaging in Precision Medicine (PRISM) in the Arkansas Imaging Enterprise System (ARIES)
title_short Semantic Integration of Multi-Modal Data and Derived Neuroimaging Results Using the Platform for Imaging in Precision Medicine (PRISM) in the Arkansas Imaging Enterprise System (ARIES)
title_sort semantic integration of multi-modal data and derived neuroimaging results using the platform for imaging in precision medicine (prism) in the arkansas imaging enterprise system (aries)
topic Artificial Intelligence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866818/
https://www.ncbi.nlm.nih.gov/pubmed/35224477
http://dx.doi.org/10.3389/frai.2021.649970
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