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Cross-sectional assessment of cardiovascular risk factors in patients with knee osteoarthritis

Background: Osteoarthritis (OA) and cardiovascular disease (CVD) are prevalent in India. However, there is dearth of literature among Indians studying the relationship between the two. This study was carried out to assess various cardiovascular (CV) risk factors in patients with knee OA with an obje...

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Autores principales: Goel, Sagar, Kamath, Surendra Umesh, Annappa, Rajendra, Krishnamurthy, Sunil Lakshmipura, Jain, Manesh, Thakkar, Samarth, Damsas, Lulu, Banerjee, Sayak, Divakar, Prajwal Madapura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866909/
https://www.ncbi.nlm.nih.gov/pubmed/35265321
http://dx.doi.org/10.12688/f1000research.27744.3
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author Goel, Sagar
Kamath, Surendra Umesh
Annappa, Rajendra
Krishnamurthy, Sunil Lakshmipura
Jain, Manesh
Thakkar, Samarth
Damsas, Lulu
Banerjee, Sayak
Divakar, Prajwal Madapura
author_facet Goel, Sagar
Kamath, Surendra Umesh
Annappa, Rajendra
Krishnamurthy, Sunil Lakshmipura
Jain, Manesh
Thakkar, Samarth
Damsas, Lulu
Banerjee, Sayak
Divakar, Prajwal Madapura
author_sort Goel, Sagar
collection PubMed
description Background: Osteoarthritis (OA) and cardiovascular disease (CVD) are prevalent in India. However, there is dearth of literature among Indians studying the relationship between the two. This study was carried out to assess various cardiovascular (CV) risk factors in patients with knee OA with an objective to investigate their association, screening and management.  Methods: In total, 225 patients were included in this cross-sectional study. Participants were diagnosed with knee OA on the basis of the Kellgren and Lawrence (K-L) classification of their radiograph. Participants were also assessed for CV risk factors; age, body mass index, systolic blood pressure, diabetes mellitus, total cholesterol, high-density lipoprotein, smoking. Joint British Society QRisk3 calculator (JBS3) a comprehensive risk score calculator as well as a screening tool, which produces three more variables, namely 10-years risk of developing CVD, physiological heart age and life expectancy, was used. Chi Square, Fishers exact test and one-way ANOVA tests were used to compare the categorical and quantitative variables, respectively.. Multiple regression analysis was done to adjust the multiple con-founders and determine their significance. Results: Patients with severe knee OA had a statistically significantly higher prevalence of CV risk factors (p<0.05). Grade 4 knee OA patients were found to have a mean JBS3 risk of 38%, heart age of 82 years and life expectancy of 77 years as compared to grade 2 patients who had a mean JBS3 risk of 11%, heart age of 63 years and life expectancy of 82 years.  Conclusions: Our study concluded that there is a strong relation between knee OA and CVD, with CV risk score being positively correlated to the severity of OA.
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spelling pubmed-88669092022-03-08 Cross-sectional assessment of cardiovascular risk factors in patients with knee osteoarthritis Goel, Sagar Kamath, Surendra Umesh Annappa, Rajendra Krishnamurthy, Sunil Lakshmipura Jain, Manesh Thakkar, Samarth Damsas, Lulu Banerjee, Sayak Divakar, Prajwal Madapura F1000Res Research Article Background: Osteoarthritis (OA) and cardiovascular disease (CVD) are prevalent in India. However, there is dearth of literature among Indians studying the relationship between the two. This study was carried out to assess various cardiovascular (CV) risk factors in patients with knee OA with an objective to investigate their association, screening and management.  Methods: In total, 225 patients were included in this cross-sectional study. Participants were diagnosed with knee OA on the basis of the Kellgren and Lawrence (K-L) classification of their radiograph. Participants were also assessed for CV risk factors; age, body mass index, systolic blood pressure, diabetes mellitus, total cholesterol, high-density lipoprotein, smoking. Joint British Society QRisk3 calculator (JBS3) a comprehensive risk score calculator as well as a screening tool, which produces three more variables, namely 10-years risk of developing CVD, physiological heart age and life expectancy, was used. Chi Square, Fishers exact test and one-way ANOVA tests were used to compare the categorical and quantitative variables, respectively.. Multiple regression analysis was done to adjust the multiple con-founders and determine their significance. Results: Patients with severe knee OA had a statistically significantly higher prevalence of CV risk factors (p<0.05). Grade 4 knee OA patients were found to have a mean JBS3 risk of 38%, heart age of 82 years and life expectancy of 77 years as compared to grade 2 patients who had a mean JBS3 risk of 11%, heart age of 63 years and life expectancy of 82 years.  Conclusions: Our study concluded that there is a strong relation between knee OA and CVD, with CV risk score being positively correlated to the severity of OA. F1000 Research Limited 2022-02-17 /pmc/articles/PMC8866909/ /pubmed/35265321 http://dx.doi.org/10.12688/f1000research.27744.3 Text en Copyright: © 2022 Goel S et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Goel, Sagar
Kamath, Surendra Umesh
Annappa, Rajendra
Krishnamurthy, Sunil Lakshmipura
Jain, Manesh
Thakkar, Samarth
Damsas, Lulu
Banerjee, Sayak
Divakar, Prajwal Madapura
Cross-sectional assessment of cardiovascular risk factors in patients with knee osteoarthritis
title Cross-sectional assessment of cardiovascular risk factors in patients with knee osteoarthritis
title_full Cross-sectional assessment of cardiovascular risk factors in patients with knee osteoarthritis
title_fullStr Cross-sectional assessment of cardiovascular risk factors in patients with knee osteoarthritis
title_full_unstemmed Cross-sectional assessment of cardiovascular risk factors in patients with knee osteoarthritis
title_short Cross-sectional assessment of cardiovascular risk factors in patients with knee osteoarthritis
title_sort cross-sectional assessment of cardiovascular risk factors in patients with knee osteoarthritis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866909/
https://www.ncbi.nlm.nih.gov/pubmed/35265321
http://dx.doi.org/10.12688/f1000research.27744.3
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