Cargando…

Alcohol-Induced Neuroinflammatory Response and Mitochondrial Dysfunction on Aging and Alzheimer’s Disease

Mitochondria are essential organelles central to various cellular functions such as energy production, metabolic pathways, signaling transduction, lipid biogenesis, and apoptosis. In the central nervous system, neurons depend on mitochondria for energy homeostasis to maintain optimal synaptic transm...

Descripción completa

Detalles Bibliográficos
Autores principales: León, Brandon Emanuel, Kang, Shinwoo, Franca-Solomon, Gabriela, Shang, Pei, Choi, Doo-Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866940/
https://www.ncbi.nlm.nih.gov/pubmed/35221939
http://dx.doi.org/10.3389/fnbeh.2021.778456
_version_ 1784655943900856320
author León, Brandon Emanuel
Kang, Shinwoo
Franca-Solomon, Gabriela
Shang, Pei
Choi, Doo-Sup
author_facet León, Brandon Emanuel
Kang, Shinwoo
Franca-Solomon, Gabriela
Shang, Pei
Choi, Doo-Sup
author_sort León, Brandon Emanuel
collection PubMed
description Mitochondria are essential organelles central to various cellular functions such as energy production, metabolic pathways, signaling transduction, lipid biogenesis, and apoptosis. In the central nervous system, neurons depend on mitochondria for energy homeostasis to maintain optimal synaptic transmission and integrity. Deficiencies in mitochondrial function, including perturbations in energy homeostasis and mitochondrial dynamics, contribute to aging, and Alzheimer’s disease. Chronic and heavy alcohol use is associated with accelerated brain aging, and increased risk for dementia, especially Alzheimer’s disease. Furthermore, through neuroimmune responses, including pro-inflammatory cytokines, excessive alcohol use induces mitochondrial dysfunction. The direct and indirect alcohol-induced neuroimmune responses, including pro-inflammatory cytokines, are critical for the relationship between alcohol-induced mitochondrial dysfunction. In the brain, alcohol activates microglia and increases inflammatory mediators that can impair mitochondrial energy production, dynamics, and initiate cell death pathways. Also, alcohol-induced cytokines in the peripheral organs indirectly, but synergistically exacerbate alcohol’s effects on brain function. This review will provide recent and advanced findings focusing on how alcohol alters the aging process and aggravates Alzheimer’s disease with a focus on mitochondrial function. Finally, we will contextualize these findings to inform clinical and therapeutic approaches towards Alzheimer’s disease.
format Online
Article
Text
id pubmed-8866940
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-88669402022-02-25 Alcohol-Induced Neuroinflammatory Response and Mitochondrial Dysfunction on Aging and Alzheimer’s Disease León, Brandon Emanuel Kang, Shinwoo Franca-Solomon, Gabriela Shang, Pei Choi, Doo-Sup Front Behav Neurosci Behavioral Neuroscience Mitochondria are essential organelles central to various cellular functions such as energy production, metabolic pathways, signaling transduction, lipid biogenesis, and apoptosis. In the central nervous system, neurons depend on mitochondria for energy homeostasis to maintain optimal synaptic transmission and integrity. Deficiencies in mitochondrial function, including perturbations in energy homeostasis and mitochondrial dynamics, contribute to aging, and Alzheimer’s disease. Chronic and heavy alcohol use is associated with accelerated brain aging, and increased risk for dementia, especially Alzheimer’s disease. Furthermore, through neuroimmune responses, including pro-inflammatory cytokines, excessive alcohol use induces mitochondrial dysfunction. The direct and indirect alcohol-induced neuroimmune responses, including pro-inflammatory cytokines, are critical for the relationship between alcohol-induced mitochondrial dysfunction. In the brain, alcohol activates microglia and increases inflammatory mediators that can impair mitochondrial energy production, dynamics, and initiate cell death pathways. Also, alcohol-induced cytokines in the peripheral organs indirectly, but synergistically exacerbate alcohol’s effects on brain function. This review will provide recent and advanced findings focusing on how alcohol alters the aging process and aggravates Alzheimer’s disease with a focus on mitochondrial function. Finally, we will contextualize these findings to inform clinical and therapeutic approaches towards Alzheimer’s disease. Frontiers Media S.A. 2022-02-10 /pmc/articles/PMC8866940/ /pubmed/35221939 http://dx.doi.org/10.3389/fnbeh.2021.778456 Text en Copyright © 2022 León, Kang, Franca-Solomon, Shang and Choi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Behavioral Neuroscience
León, Brandon Emanuel
Kang, Shinwoo
Franca-Solomon, Gabriela
Shang, Pei
Choi, Doo-Sup
Alcohol-Induced Neuroinflammatory Response and Mitochondrial Dysfunction on Aging and Alzheimer’s Disease
title Alcohol-Induced Neuroinflammatory Response and Mitochondrial Dysfunction on Aging and Alzheimer’s Disease
title_full Alcohol-Induced Neuroinflammatory Response and Mitochondrial Dysfunction on Aging and Alzheimer’s Disease
title_fullStr Alcohol-Induced Neuroinflammatory Response and Mitochondrial Dysfunction on Aging and Alzheimer’s Disease
title_full_unstemmed Alcohol-Induced Neuroinflammatory Response and Mitochondrial Dysfunction on Aging and Alzheimer’s Disease
title_short Alcohol-Induced Neuroinflammatory Response and Mitochondrial Dysfunction on Aging and Alzheimer’s Disease
title_sort alcohol-induced neuroinflammatory response and mitochondrial dysfunction on aging and alzheimer’s disease
topic Behavioral Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866940/
https://www.ncbi.nlm.nih.gov/pubmed/35221939
http://dx.doi.org/10.3389/fnbeh.2021.778456
work_keys_str_mv AT leonbrandonemanuel alcoholinducedneuroinflammatoryresponseandmitochondrialdysfunctiononagingandalzheimersdisease
AT kangshinwoo alcoholinducedneuroinflammatoryresponseandmitochondrialdysfunctiononagingandalzheimersdisease
AT francasolomongabriela alcoholinducedneuroinflammatoryresponseandmitochondrialdysfunctiononagingandalzheimersdisease
AT shangpei alcoholinducedneuroinflammatoryresponseandmitochondrialdysfunctiononagingandalzheimersdisease
AT choidoosup alcoholinducedneuroinflammatoryresponseandmitochondrialdysfunctiononagingandalzheimersdisease