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Retinal Nerve Fiber Layer Thickness and Associations With Cognitive Impairment in Parkinson’s Disease

OBJECTIVE: This study intended to investigate whether retinal nerve fiber layer (RNFL) thickness could become a potential marker in patients with Parkinson’s disease with cognitive impairment (PD-CI). METHODS: Fifty-seven PD patients and 45 age-matched healthy controls (HCs) were recruited in our cr...

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Autores principales: Chang, Zihan, Xie, Fen, Li, Hualing, Yuan, Feilan, Zeng, Lina, Shi, Lin, Zhu, Shuzhen, Lu, Xiaohe, Wei, Xiaobo, Wang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867012/
https://www.ncbi.nlm.nih.gov/pubmed/35222000
http://dx.doi.org/10.3389/fnagi.2022.832768
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author Chang, Zihan
Xie, Fen
Li, Hualing
Yuan, Feilan
Zeng, Lina
Shi, Lin
Zhu, Shuzhen
Lu, Xiaohe
Wei, Xiaobo
Wang, Qing
author_facet Chang, Zihan
Xie, Fen
Li, Hualing
Yuan, Feilan
Zeng, Lina
Shi, Lin
Zhu, Shuzhen
Lu, Xiaohe
Wei, Xiaobo
Wang, Qing
author_sort Chang, Zihan
collection PubMed
description OBJECTIVE: This study intended to investigate whether retinal nerve fiber layer (RNFL) thickness could become a potential marker in patients with Parkinson’s disease with cognitive impairment (PD-CI). METHODS: Fifty-seven PD patients and 45 age-matched healthy controls (HCs) were recruited in our cross-sectional study and completed optical coherence tomography (OCT) evaluations. PD with normal cognition (PD-NC) and cognitive impairment (PD-CI) patients were divided following the 2015 Movement Disorder Society criteria. RNFL thickness was quantified in subfields of the 3.0-mm circle surrounding the optic disk; while a battery of neuropsychiatric assessments was conducted to estimate the Parkinsonism severity. General linear models and one-way ANOVA were adopted to assess RNFL thickness between subgroups with different cognitive statuses; logistic regression analyses were applied to determine the relation between RNFL and PD-CI cases. RESULTS: Compared with HCs, more thinning of the RNFL was observed in the inferior and temporal sectors in PD patients, especially in the PD-CI group. Inferior RNFL thickness was reduced in PD-CI compared with PD-NC patients. Logistic regression analysis found that inferior RNFL thickness was independently associated with PD-CI cases (odds ratio = 0.923, p = 0.014). Receiver operating characteristic analysis showed that the RNFL-involved combined model provided a high accuracy in screening cognitive deficiency in PD cases (area under the curve = 0.85, p < 0.001). CONCLUSION: Reduced RNFL thickness especially in the inferior sector is independently associated with PD-CI patients. Our study present new perspectives into verifying possible indicators for neuropathological processes or disease severity in Parkinsonians with cognitive dysfunction.
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spelling pubmed-88670122022-02-25 Retinal Nerve Fiber Layer Thickness and Associations With Cognitive Impairment in Parkinson’s Disease Chang, Zihan Xie, Fen Li, Hualing Yuan, Feilan Zeng, Lina Shi, Lin Zhu, Shuzhen Lu, Xiaohe Wei, Xiaobo Wang, Qing Front Aging Neurosci Neuroscience OBJECTIVE: This study intended to investigate whether retinal nerve fiber layer (RNFL) thickness could become a potential marker in patients with Parkinson’s disease with cognitive impairment (PD-CI). METHODS: Fifty-seven PD patients and 45 age-matched healthy controls (HCs) were recruited in our cross-sectional study and completed optical coherence tomography (OCT) evaluations. PD with normal cognition (PD-NC) and cognitive impairment (PD-CI) patients were divided following the 2015 Movement Disorder Society criteria. RNFL thickness was quantified in subfields of the 3.0-mm circle surrounding the optic disk; while a battery of neuropsychiatric assessments was conducted to estimate the Parkinsonism severity. General linear models and one-way ANOVA were adopted to assess RNFL thickness between subgroups with different cognitive statuses; logistic regression analyses were applied to determine the relation between RNFL and PD-CI cases. RESULTS: Compared with HCs, more thinning of the RNFL was observed in the inferior and temporal sectors in PD patients, especially in the PD-CI group. Inferior RNFL thickness was reduced in PD-CI compared with PD-NC patients. Logistic regression analysis found that inferior RNFL thickness was independently associated with PD-CI cases (odds ratio = 0.923, p = 0.014). Receiver operating characteristic analysis showed that the RNFL-involved combined model provided a high accuracy in screening cognitive deficiency in PD cases (area under the curve = 0.85, p < 0.001). CONCLUSION: Reduced RNFL thickness especially in the inferior sector is independently associated with PD-CI patients. Our study present new perspectives into verifying possible indicators for neuropathological processes or disease severity in Parkinsonians with cognitive dysfunction. Frontiers Media S.A. 2022-02-10 /pmc/articles/PMC8867012/ /pubmed/35222000 http://dx.doi.org/10.3389/fnagi.2022.832768 Text en Copyright © 2022 Chang, Xie, Li, Yuan, Zeng, Shi, Zhu, Lu, Wei and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Chang, Zihan
Xie, Fen
Li, Hualing
Yuan, Feilan
Zeng, Lina
Shi, Lin
Zhu, Shuzhen
Lu, Xiaohe
Wei, Xiaobo
Wang, Qing
Retinal Nerve Fiber Layer Thickness and Associations With Cognitive Impairment in Parkinson’s Disease
title Retinal Nerve Fiber Layer Thickness and Associations With Cognitive Impairment in Parkinson’s Disease
title_full Retinal Nerve Fiber Layer Thickness and Associations With Cognitive Impairment in Parkinson’s Disease
title_fullStr Retinal Nerve Fiber Layer Thickness and Associations With Cognitive Impairment in Parkinson’s Disease
title_full_unstemmed Retinal Nerve Fiber Layer Thickness and Associations With Cognitive Impairment in Parkinson’s Disease
title_short Retinal Nerve Fiber Layer Thickness and Associations With Cognitive Impairment in Parkinson’s Disease
title_sort retinal nerve fiber layer thickness and associations with cognitive impairment in parkinson’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867012/
https://www.ncbi.nlm.nih.gov/pubmed/35222000
http://dx.doi.org/10.3389/fnagi.2022.832768
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