Gut-innervating TRPV1+ Neurons Drive Chronic Visceral Pain via Microglial P2Y12 Receptor

BACKGROUND & AIMS: Chronic abdominal pain is a common symptom of inflammatory bowel diseases (IBDs). Peripheral and central mechanisms contribute to the transition from acute to chronic pain during active disease and clinical remission. Lower mechanical threshold and hyperexcitability of viscera...

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Detalles Bibliográficos
Autores principales: Defaye, Manon, Abdullah, Nasser S., Iftinca, Mircea, Hassan, Ahmed, Agosti, Francina, Zhang, Zizhen, Cumenal, Melissa, Zamponi, Gerald W., Altier, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867057/
https://www.ncbi.nlm.nih.gov/pubmed/34954381
http://dx.doi.org/10.1016/j.jcmgh.2021.12.012

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