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Substrate specificity and proposed structure of the proofreading complex of T7 DNA polymerase

Faithful replication of genomic DNA by high-fidelity DNA polymerases is crucial for the survival of most living organisms. While high-fidelity DNA polymerases favor canonical base pairs over mismatches by a factor of ∼1 × 10(5), fidelity is further enhanced several orders of magnitude by a 3′–5′ pro...

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Detalles Bibliográficos
Autores principales:	Dangerfield, Tyler L., Kirmizialtin, Serdal, Johnson, Kenneth A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867116/ https://www.ncbi.nlm.nih.gov/pubmed/35074426 http://dx.doi.org/10.1016/j.jbc.2022.101627

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