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Exploring the super-relaxed state of myosin in myofibrils from fast-twitch, slow-twitch, and cardiac muscle

Muscle myosin heads, in the absence of actin, have been shown to exist in two states, the relaxed (turnover ∼0.05 s(−1)) and super-relaxed states (SRX, 0.005 s(−1)) using a simple fluorescent ATP chase assay (Hooijman, P. et al (2011) Biophys. J.100, 1969–1976). Studies have normally used purified p...

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Detalles Bibliográficos
Autores principales: Walklate, Jonathan, Kao, Kerry, Regnier, Michael, Geeves, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867123/
https://www.ncbi.nlm.nih.gov/pubmed/35090895
http://dx.doi.org/10.1016/j.jbc.2022.101640