Copper(II) import and reduction are dependent on His-Met clusters in the extracellular amino terminus of human copper transporter-1

Copper(I) is an essential metal for all life forms. Though Cu(II) is the most abundant and stable state, its reduction to Cu(I) via an unclear mechanism is prerequisite for its bioutilization. In eukaryotes, the copper transporter-1 (CTR1) is the primary high-affinity copper importer, although its m...

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Detalles Bibliográficos
Autores principales: Kar, Sumanta, Sen, Samarpita, Maji, Saptarshi, Saraf, Deepashri, Ruturaj, Paul, Rupam, Dutt, Sohini, Mondal, Basudeb, Rodriguez-Boulan, Enrique, Schreiner, Ryan, Sengupta, Durba, Gupta, Arnab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867124/
https://www.ncbi.nlm.nih.gov/pubmed/35090891
http://dx.doi.org/10.1016/j.jbc.2022.101631

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