Regulatory Variant rs2535629 in ITIH3 Intron Confers Schizophrenia Risk By Regulating CTCF Binding and SFMBT1 Expression

Genome‐wide association studies have identified 3p21.1 as a robust risk locus for schizophrenia. However, the underlying molecular mechanisms remain elusive. Here a functional regulatory variant (rs2535629) is identified that disrupts CTCF binding at 3p21.1. It is confirmed that rs2535629 is also si...

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Detalles Bibliográficos
Autores principales: Li, Yifan, Ma, Changguo, Li, Shiwu, Wang, Junyang, Li, Wenqiang, Yang, Yongfeng, Li, Xiaoyan, Liu, Jiewei, Yang, Jinfeng, Liu, Yixing, Li, Kaiqin, Li, Jiao, Huang, Di, Chen, Rui, Lv, Luxian, Xiao, Xiao, Li, Ming, Luo, Xiong‐Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867204/
https://www.ncbi.nlm.nih.gov/pubmed/34978167
http://dx.doi.org/10.1002/advs.202104786

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