Oncolytic adenovirus decreases the proportion of TIM-3(+) subset of tumor-infiltrating CD8(+) T cells with correlation to improved survival in patients with cancer

BACKGROUND: Oncolytic viruses are a potent form of active immunotherapy, capable of invoking antitumor T-cell responses. Meanwhile, less is known about their effects on immune checkpoints, the main targets for passive immunotherapy of cancer. T-cell immunoglobulin and mucin domain-3 (TIM-3) is a coi...

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Detalles Bibliográficos
Autores principales: Liikanen, Ilkka, Basnet, Saru, Quixabeira, Dafne C A, Taipale, Kristian, Hemminki, Otto, Oksanen, Minna, Kankainen, Matti, Juhila, Juuso, Kanerva, Anna, Joensuu, Timo, Tähtinen, Siri, Hemminki, Akseli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Oncolytic and Local Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867324/
https://www.ncbi.nlm.nih.gov/pubmed/35193929
http://dx.doi.org/10.1136/jitc-2021-003490

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