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Respiratory failure as the prominent manifestation of entecavir-associated mitochondrial myopathy: a case report

BACKGROUND: Mitochondrial myopathy caused by the long-term use of nucleos(t)ide analogue in patients with chronic hepatitis B (CHB) is mostly characterized by myasthenia and myalgia. Cases with respiratory failure as the prominent manifestation and multisystem symptoms have not been reported. CASE R...

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Autores principales: Lin, Xiao, Song, Aixin, Zheng, Sujun, Chen, Xinyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867453/
https://www.ncbi.nlm.nih.gov/pubmed/35209862
http://dx.doi.org/10.1186/s12879-022-07159-y
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author Lin, Xiao
Song, Aixin
Zheng, Sujun
Chen, Xinyue
author_facet Lin, Xiao
Song, Aixin
Zheng, Sujun
Chen, Xinyue
author_sort Lin, Xiao
collection PubMed
description BACKGROUND: Mitochondrial myopathy caused by the long-term use of nucleos(t)ide analogue in patients with chronic hepatitis B (CHB) is mostly characterized by myasthenia and myalgia. Cases with respiratory failure as the prominent manifestation and multisystem symptoms have not been reported. CASE REPORT: We report a case of mitochondrial myopathy associated with the long-term use of entecavir for CHB. The patient was a 54-year-old male who was treated with entecavir for 9 years. During the treatment, hepatitis B virus (HBV) DNA was negative and liver function was normal. However, generalized fatigue, poor appetite, dysosmia and other discomforts gradually presented starting at the 5(th) year of treatment, and respiratory failure was the prominent manifestation in the later stage of disease progression. The diagnosis was based on histopathology examination. The dysosmia, hypoxemia and digestive tract symptoms were gradually improved after withdrawal of entecavir. DISCUSSION: Mitochondrial myopathy is a rare side effect of entecavir and can be diagnosed by muscle biopsy. Although the incidence is extremely low, but the severe cases can lead to respiratory failure. We should receive adequate attention in clinical practice.
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spelling pubmed-88674532022-02-24 Respiratory failure as the prominent manifestation of entecavir-associated mitochondrial myopathy: a case report Lin, Xiao Song, Aixin Zheng, Sujun Chen, Xinyue BMC Infect Dis Case Report BACKGROUND: Mitochondrial myopathy caused by the long-term use of nucleos(t)ide analogue in patients with chronic hepatitis B (CHB) is mostly characterized by myasthenia and myalgia. Cases with respiratory failure as the prominent manifestation and multisystem symptoms have not been reported. CASE REPORT: We report a case of mitochondrial myopathy associated with the long-term use of entecavir for CHB. The patient was a 54-year-old male who was treated with entecavir for 9 years. During the treatment, hepatitis B virus (HBV) DNA was negative and liver function was normal. However, generalized fatigue, poor appetite, dysosmia and other discomforts gradually presented starting at the 5(th) year of treatment, and respiratory failure was the prominent manifestation in the later stage of disease progression. The diagnosis was based on histopathology examination. The dysosmia, hypoxemia and digestive tract symptoms were gradually improved after withdrawal of entecavir. DISCUSSION: Mitochondrial myopathy is a rare side effect of entecavir and can be diagnosed by muscle biopsy. Although the incidence is extremely low, but the severe cases can lead to respiratory failure. We should receive adequate attention in clinical practice. BioMed Central 2022-02-24 /pmc/articles/PMC8867453/ /pubmed/35209862 http://dx.doi.org/10.1186/s12879-022-07159-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Lin, Xiao
Song, Aixin
Zheng, Sujun
Chen, Xinyue
Respiratory failure as the prominent manifestation of entecavir-associated mitochondrial myopathy: a case report
title Respiratory failure as the prominent manifestation of entecavir-associated mitochondrial myopathy: a case report
title_full Respiratory failure as the prominent manifestation of entecavir-associated mitochondrial myopathy: a case report
title_fullStr Respiratory failure as the prominent manifestation of entecavir-associated mitochondrial myopathy: a case report
title_full_unstemmed Respiratory failure as the prominent manifestation of entecavir-associated mitochondrial myopathy: a case report
title_short Respiratory failure as the prominent manifestation of entecavir-associated mitochondrial myopathy: a case report
title_sort respiratory failure as the prominent manifestation of entecavir-associated mitochondrial myopathy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867453/
https://www.ncbi.nlm.nih.gov/pubmed/35209862
http://dx.doi.org/10.1186/s12879-022-07159-y
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AT zhengsujun respiratoryfailureastheprominentmanifestationofentecavirassociatedmitochondrialmyopathyacasereport
AT chenxinyue respiratoryfailureastheprominentmanifestationofentecavirassociatedmitochondrialmyopathyacasereport