Cytokine Release Syndrome Following Blinatumomab Therapy

New therapeutic solutions have emerged in the last few decades with the growth and expansion of the field of cancer research. Amongst these new agents, immunotherapy has been prominent, particularly regarding the treatment of hematologic malignancies. One of the most worrisome complications of immun...

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Autores principales: Ojemolon, Pius E, Kalidindi, Sunaina, Ahlborn, Taylor A, Aihie, Osaigbokan P, Awoyomi, Moyosoluwa I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867529/
https://www.ncbi.nlm.nih.gov/pubmed/35228941
http://dx.doi.org/10.7759/cureus.21583
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author Ojemolon, Pius E
Kalidindi, Sunaina
Ahlborn, Taylor A
Aihie, Osaigbokan P
Awoyomi, Moyosoluwa I
author_facet Ojemolon, Pius E
Kalidindi, Sunaina
Ahlborn, Taylor A
Aihie, Osaigbokan P
Awoyomi, Moyosoluwa I
author_sort Ojemolon, Pius E
collection PubMed
description New therapeutic solutions have emerged in the last few decades with the growth and expansion of the field of cancer research. Amongst these new agents, immunotherapy has been prominent, particularly regarding the treatment of hematologic malignancies. One of the most worrisome complications of immunotherapy is cytokine release syndrome (CRS), which represents a supraphysiologic response resulting in excessive release of cytokines and a wide range of systemic manifestations. In this case report, we present a case of cytokine release syndrome following blinatumomab therapy despite premedication with dexamethasone.
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spelling pubmed-88675292022-02-27 Cytokine Release Syndrome Following Blinatumomab Therapy Ojemolon, Pius E Kalidindi, Sunaina Ahlborn, Taylor A Aihie, Osaigbokan P Awoyomi, Moyosoluwa I Cureus Internal Medicine New therapeutic solutions have emerged in the last few decades with the growth and expansion of the field of cancer research. Amongst these new agents, immunotherapy has been prominent, particularly regarding the treatment of hematologic malignancies. One of the most worrisome complications of immunotherapy is cytokine release syndrome (CRS), which represents a supraphysiologic response resulting in excessive release of cytokines and a wide range of systemic manifestations. In this case report, we present a case of cytokine release syndrome following blinatumomab therapy despite premedication with dexamethasone. Cureus 2022-01-25 /pmc/articles/PMC8867529/ /pubmed/35228941 http://dx.doi.org/10.7759/cureus.21583 Text en Copyright © 2022, Ojemolon et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Ojemolon, Pius E
Kalidindi, Sunaina
Ahlborn, Taylor A
Aihie, Osaigbokan P
Awoyomi, Moyosoluwa I
Cytokine Release Syndrome Following Blinatumomab Therapy
title Cytokine Release Syndrome Following Blinatumomab Therapy
title_full Cytokine Release Syndrome Following Blinatumomab Therapy
title_fullStr Cytokine Release Syndrome Following Blinatumomab Therapy
title_full_unstemmed Cytokine Release Syndrome Following Blinatumomab Therapy
title_short Cytokine Release Syndrome Following Blinatumomab Therapy
title_sort cytokine release syndrome following blinatumomab therapy
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867529/
https://www.ncbi.nlm.nih.gov/pubmed/35228941
http://dx.doi.org/10.7759/cureus.21583
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AT aihieosaigbokanp cytokinereleasesyndromefollowingblinatumomabtherapy
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