Functionalized Boron Nanoparticles as Potential Promising Antimalarial Agents

[Image: see text] Boron nanoparticles (BNPs), functionalized with hydroxyl groups, were synthesized in situ by a cascade process, followed by bromination and hydrolyzation reactions. These functionalized BNPs, (B(m)(OH)(n)), were characterized using (1)H and (11)B NMR spectra, Fourier-transform infr...

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Autores principales: Zhu, Yinghuai, Prommana, Parichat, Hosmane, Narayan S., Coghi, Paolo, Uthaipibull, Chairat, Zhang, Yingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867546/
https://www.ncbi.nlm.nih.gov/pubmed/35224347
http://dx.doi.org/10.1021/acsomega.1c05888
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author Zhu, Yinghuai
Prommana, Parichat
Hosmane, Narayan S.
Coghi, Paolo
Uthaipibull, Chairat
Zhang, Yingjun
author_facet Zhu, Yinghuai
Prommana, Parichat
Hosmane, Narayan S.
Coghi, Paolo
Uthaipibull, Chairat
Zhang, Yingjun
author_sort Zhu, Yinghuai
collection PubMed
description [Image: see text] Boron nanoparticles (BNPs), functionalized with hydroxyl groups, were synthesized in situ by a cascade process, followed by bromination and hydrolyzation reactions. These functionalized BNPs, (B(m)(OH)(n)), were characterized using (1)H and (11)B NMR spectra, Fourier-transform infrared (FT-IR) spectroscopy, inductively coupled plasma-optical emission spectroscopy (ICP-OES), transmission electron microscopy (TEM), dynamic light scattering (DLS), and X-ray photoelectron spectroscopy (XPS) methods. These nanoparticles were also evaluated in vitro for their antimalarial activity against Plasmodium falciparum (3D7 strain) with an IC(50) value of 0.0021 μM and showed low toxicity to Uppsala 87 malignant glioma (U87MG) cell lines, malignant melanoma A375 cell lines, KB human oral cancer cell lines, rat cortical neuron cell lines, and rat fibroblast-like synoviocyte (FLS) cell lines.
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spelling pubmed-88675462022-02-25 Functionalized Boron Nanoparticles as Potential Promising Antimalarial Agents Zhu, Yinghuai Prommana, Parichat Hosmane, Narayan S. Coghi, Paolo Uthaipibull, Chairat Zhang, Yingjun ACS Omega [Image: see text] Boron nanoparticles (BNPs), functionalized with hydroxyl groups, were synthesized in situ by a cascade process, followed by bromination and hydrolyzation reactions. These functionalized BNPs, (B(m)(OH)(n)), were characterized using (1)H and (11)B NMR spectra, Fourier-transform infrared (FT-IR) spectroscopy, inductively coupled plasma-optical emission spectroscopy (ICP-OES), transmission electron microscopy (TEM), dynamic light scattering (DLS), and X-ray photoelectron spectroscopy (XPS) methods. These nanoparticles were also evaluated in vitro for their antimalarial activity against Plasmodium falciparum (3D7 strain) with an IC(50) value of 0.0021 μM and showed low toxicity to Uppsala 87 malignant glioma (U87MG) cell lines, malignant melanoma A375 cell lines, KB human oral cancer cell lines, rat cortical neuron cell lines, and rat fibroblast-like synoviocyte (FLS) cell lines. American Chemical Society 2022-02-09 /pmc/articles/PMC8867546/ /pubmed/35224347 http://dx.doi.org/10.1021/acsomega.1c05888 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Zhu, Yinghuai
Prommana, Parichat
Hosmane, Narayan S.
Coghi, Paolo
Uthaipibull, Chairat
Zhang, Yingjun
Functionalized Boron Nanoparticles as Potential Promising Antimalarial Agents
title Functionalized Boron Nanoparticles as Potential Promising Antimalarial Agents
title_full Functionalized Boron Nanoparticles as Potential Promising Antimalarial Agents
title_fullStr Functionalized Boron Nanoparticles as Potential Promising Antimalarial Agents
title_full_unstemmed Functionalized Boron Nanoparticles as Potential Promising Antimalarial Agents
title_short Functionalized Boron Nanoparticles as Potential Promising Antimalarial Agents
title_sort functionalized boron nanoparticles as potential promising antimalarial agents
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867546/
https://www.ncbi.nlm.nih.gov/pubmed/35224347
http://dx.doi.org/10.1021/acsomega.1c05888
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