Camphorsulfonic Acid-Mediated One-Pot Tandem Consecutive via the Ugi Four-Component Reaction for the Synthesis of Functionalized Indole and 2-Quinolone Derivatives by Switching Solvents

[Image: see text] A camphorsulfonic acid-mediated one-pot tandem consecutive approach was developed to synthesize functionalized indole and 2-quinolone derivatives from the Ugi four-component reaction by switching solvents. A reaction of the Ugi adduct in an aprotic solvent undergoes 5-exo-trig cycl...

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Autores principales: Murugan, Sivan Perumal, Zhong, Hong-Jie, Wu, Chih-Yu, Pan, Hao-Wei, Chen, Chinpiao, Lee, Gene-Hsian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867550/
https://www.ncbi.nlm.nih.gov/pubmed/35224332
http://dx.doi.org/10.1021/acsomega.1c05460
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author Murugan, Sivan Perumal
Zhong, Hong-Jie
Wu, Chih-Yu
Pan, Hao-Wei
Chen, Chinpiao
Lee, Gene-Hsian
author_facet Murugan, Sivan Perumal
Zhong, Hong-Jie
Wu, Chih-Yu
Pan, Hao-Wei
Chen, Chinpiao
Lee, Gene-Hsian
author_sort Murugan, Sivan Perumal
collection PubMed
description [Image: see text] A camphorsulfonic acid-mediated one-pot tandem consecutive approach was developed to synthesize functionalized indole and 2-quinolone derivatives from the Ugi four-component reaction by switching solvents. A reaction of the Ugi adduct in an aprotic solvent undergoes 5-exo-trig cyclization to form an indole ring. In a protic solvent, however, the Ugi adduct undergoes an alkyne-carbonyl metathesis reaction to form a 2-quinolone ring.
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spelling pubmed-88675502022-02-25 Camphorsulfonic Acid-Mediated One-Pot Tandem Consecutive via the Ugi Four-Component Reaction for the Synthesis of Functionalized Indole and 2-Quinolone Derivatives by Switching Solvents Murugan, Sivan Perumal Zhong, Hong-Jie Wu, Chih-Yu Pan, Hao-Wei Chen, Chinpiao Lee, Gene-Hsian ACS Omega [Image: see text] A camphorsulfonic acid-mediated one-pot tandem consecutive approach was developed to synthesize functionalized indole and 2-quinolone derivatives from the Ugi four-component reaction by switching solvents. A reaction of the Ugi adduct in an aprotic solvent undergoes 5-exo-trig cyclization to form an indole ring. In a protic solvent, however, the Ugi adduct undergoes an alkyne-carbonyl metathesis reaction to form a 2-quinolone ring. American Chemical Society 2022-02-10 /pmc/articles/PMC8867550/ /pubmed/35224332 http://dx.doi.org/10.1021/acsomega.1c05460 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Murugan, Sivan Perumal
Zhong, Hong-Jie
Wu, Chih-Yu
Pan, Hao-Wei
Chen, Chinpiao
Lee, Gene-Hsian
Camphorsulfonic Acid-Mediated One-Pot Tandem Consecutive via the Ugi Four-Component Reaction for the Synthesis of Functionalized Indole and 2-Quinolone Derivatives by Switching Solvents
title Camphorsulfonic Acid-Mediated One-Pot Tandem Consecutive via the Ugi Four-Component Reaction for the Synthesis of Functionalized Indole and 2-Quinolone Derivatives by Switching Solvents
title_full Camphorsulfonic Acid-Mediated One-Pot Tandem Consecutive via the Ugi Four-Component Reaction for the Synthesis of Functionalized Indole and 2-Quinolone Derivatives by Switching Solvents
title_fullStr Camphorsulfonic Acid-Mediated One-Pot Tandem Consecutive via the Ugi Four-Component Reaction for the Synthesis of Functionalized Indole and 2-Quinolone Derivatives by Switching Solvents
title_full_unstemmed Camphorsulfonic Acid-Mediated One-Pot Tandem Consecutive via the Ugi Four-Component Reaction for the Synthesis of Functionalized Indole and 2-Quinolone Derivatives by Switching Solvents
title_short Camphorsulfonic Acid-Mediated One-Pot Tandem Consecutive via the Ugi Four-Component Reaction for the Synthesis of Functionalized Indole and 2-Quinolone Derivatives by Switching Solvents
title_sort camphorsulfonic acid-mediated one-pot tandem consecutive via the ugi four-component reaction for the synthesis of functionalized indole and 2-quinolone derivatives by switching solvents
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867550/
https://www.ncbi.nlm.nih.gov/pubmed/35224332
http://dx.doi.org/10.1021/acsomega.1c05460
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