CeRebrUm and CardIac Protection with ALlopurinol in Neonates with Critical Congenital Heart Disease Requiring Cardiac Surgery with Cardiopulmonary Bypass (CRUCIAL): study protocol of a phase III, randomized, quadruple-blinded, placebo-controlled, Dutch multicenter trial

BACKGROUND: Neonates with critical congenital heart disease (CCHD) undergoing cardiac surgery with cardiopulmonary bypass (CPB) are at risk of brain injury that may result in adverse neurodevelopment. To date, no therapy is available to improve long-term neurodevelopmental outcomes of CCHD neonates....

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Detalles Bibliográficos
Autores principales: Stegeman, Raymond, Nijman, Maaike, Breur, Johannes M. P. J., Groenendaal, Floris, Haas, Felix, Derks, Jan B., Nijman, Joppe, van Beynum, Ingrid M., Taverne, Yannick J. H. J., Bogers, Ad J. J. C., Helbing, Willem A., de Boode, Willem P., Bos, Arend F., Berger, Rolf M. F., Accord, Ryan E., Roes, Kit C. B., de Wit, G. Ardine, Jansen, Nicolaas J. G., Benders, Manon J. N. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867620/
https://www.ncbi.nlm.nih.gov/pubmed/35197082
http://dx.doi.org/10.1186/s13063-022-06098-y

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