Practical and Scalable Manufacturing Process for the Key Intermediate of Poly(ADP-Ribose) Polymerase Inhibitor Olaparib

[Image: see text] Olaparib (Lynparza) is a potent, highly selective inhibitor of poly(ADP-ribose)polymerase enzymes, approved by the U.S. FDA and EMA for the treatment of ovarian cancer. Herein, we report a practical, economical, and scalable process for the synthesis of 2-fluoro-5-((4-oxo-3,4-dihyd...

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Detalles Bibliográficos
Autores principales: Chen, Zhaohang, Wang, Shuai, Liu, Kangjie, Zhang, Rui, Li, Qiaoying, Bian, Weiguang, Qiao, Renzhong, Li, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867798/
https://www.ncbi.nlm.nih.gov/pubmed/35224393
http://dx.doi.org/10.1021/acsomega.1c06920

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