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Enhancement of Curcuma xanthorrhiza Roxb Phytochemical Dissolution via Micronization Using a Supercritical Antisolvent Technique

[Image: see text] Fine particles comprising Curcuma xanthorrhiza Roxb (C. xanthorrhiza) rhizome extract were successfully generated using a supercritical carbon dioxide (SCCO(2)) antisolvent technique. The SCCO(2) antisolvent process was performed at 40 °C with 8–16 MPa operating pressures. The CO(2...

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Autores principales: Machmudah, Siti, Mahardika, Rizky Prasetya, Almadilla, Syahna, Winardi, Sugeng, Wahyudiono, Kanda, Hideki, Goto, Motonobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867802/
https://www.ncbi.nlm.nih.gov/pubmed/35224396
http://dx.doi.org/10.1021/acsomega.1c06911
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author Machmudah, Siti
Mahardika, Rizky Prasetya
Almadilla, Syahna
Winardi, Sugeng
Wahyudiono,
Kanda, Hideki
Goto, Motonobu
author_facet Machmudah, Siti
Mahardika, Rizky Prasetya
Almadilla, Syahna
Winardi, Sugeng
Wahyudiono,
Kanda, Hideki
Goto, Motonobu
author_sort Machmudah, Siti
collection PubMed
description [Image: see text] Fine particles comprising Curcuma xanthorrhiza Roxb (C. xanthorrhiza) rhizome extract were successfully generated using a supercritical carbon dioxide (SCCO(2)) antisolvent technique. The SCCO(2) antisolvent process was performed at 40 °C with 8–16 MPa operating pressures. The CO(2) and feed solution flow rates were 15 and 0.25 mL min(–1), respectively. The mixture of C. xanthorrhiza rhizome extract and a polyvinylpyrrolidone (PVP) polymer in acetone–ethanol was used as a feed solution. The collected particle products seemed to possess spherical and spherical-like morphologies with a diameter of less than 500 nm. The infrared spectroscopy analysis showed that the structural properties of C. xanthorrhiza rhizome extract did not change after treatment with the SCCO(2) antisolvent. Furthermore, the addition of the PVP polymer in the C. xanthorrhiza rhizome extract particle products may improve their dissolution significantly in an aqueous solution medium.
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spelling pubmed-88678022022-02-25 Enhancement of Curcuma xanthorrhiza Roxb Phytochemical Dissolution via Micronization Using a Supercritical Antisolvent Technique Machmudah, Siti Mahardika, Rizky Prasetya Almadilla, Syahna Winardi, Sugeng Wahyudiono, Kanda, Hideki Goto, Motonobu ACS Omega [Image: see text] Fine particles comprising Curcuma xanthorrhiza Roxb (C. xanthorrhiza) rhizome extract were successfully generated using a supercritical carbon dioxide (SCCO(2)) antisolvent technique. The SCCO(2) antisolvent process was performed at 40 °C with 8–16 MPa operating pressures. The CO(2) and feed solution flow rates were 15 and 0.25 mL min(–1), respectively. The mixture of C. xanthorrhiza rhizome extract and a polyvinylpyrrolidone (PVP) polymer in acetone–ethanol was used as a feed solution. The collected particle products seemed to possess spherical and spherical-like morphologies with a diameter of less than 500 nm. The infrared spectroscopy analysis showed that the structural properties of C. xanthorrhiza rhizome extract did not change after treatment with the SCCO(2) antisolvent. Furthermore, the addition of the PVP polymer in the C. xanthorrhiza rhizome extract particle products may improve their dissolution significantly in an aqueous solution medium. American Chemical Society 2022-02-08 /pmc/articles/PMC8867802/ /pubmed/35224396 http://dx.doi.org/10.1021/acsomega.1c06911 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Machmudah, Siti
Mahardika, Rizky Prasetya
Almadilla, Syahna
Winardi, Sugeng
Wahyudiono,
Kanda, Hideki
Goto, Motonobu
Enhancement of Curcuma xanthorrhiza Roxb Phytochemical Dissolution via Micronization Using a Supercritical Antisolvent Technique
title Enhancement of Curcuma xanthorrhiza Roxb Phytochemical Dissolution via Micronization Using a Supercritical Antisolvent Technique
title_full Enhancement of Curcuma xanthorrhiza Roxb Phytochemical Dissolution via Micronization Using a Supercritical Antisolvent Technique
title_fullStr Enhancement of Curcuma xanthorrhiza Roxb Phytochemical Dissolution via Micronization Using a Supercritical Antisolvent Technique
title_full_unstemmed Enhancement of Curcuma xanthorrhiza Roxb Phytochemical Dissolution via Micronization Using a Supercritical Antisolvent Technique
title_short Enhancement of Curcuma xanthorrhiza Roxb Phytochemical Dissolution via Micronization Using a Supercritical Antisolvent Technique
title_sort enhancement of curcuma xanthorrhiza roxb phytochemical dissolution via micronization using a supercritical antisolvent technique
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867802/
https://www.ncbi.nlm.nih.gov/pubmed/35224396
http://dx.doi.org/10.1021/acsomega.1c06911
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