Safety and efficacy of MIKE-1 in patients with advanced pancreatic cancer: a study protocol for an open-label phase I/II investigator-initiated clinical trial based on a drug repositioning approach that reprograms the tumour stroma

BACKGROUND: Cancer-associated fibroblasts (CAFs) are an important component of the tumour microenvironment. Recent studies revealed CAFs are heterogeneous and CAF subset(s) that suppress cancer progression (cancer-restraining CAFs [rCAFs]) must exist in addition to well-characterised cancer-promotin...

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Detalles Bibliográficos
Autores principales: Mizutani, Yasuyuki, Iida, Tadashi, Ohno, Eizaburo, Ishikawa, Takuya, Kinoshita, Fumie, Kuwatsuka, Yachiyo, Imai, Miwa, Shimizu, Shinobu, Tsuruta, Toshihisa, Enomoto, Atsushi, Kawashima, Hiroki, Fujishiro, Mitsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867831/
https://www.ncbi.nlm.nih.gov/pubmed/35209871
http://dx.doi.org/10.1186/s12885-022-09272-2

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