Proton magnetic resonance spectroscopy detects cerebral metabolic derangement in a mouse model of brain coenzyme a deficiency

BACKGROUND: Pantothenate kinase (PANK) is the first and rate-controlling enzymatic step in the only pathway for cellular coenzyme A (CoA) biosynthesis. PANK-associated neurodegeneration (PKAN), formerly known as Hallervorden–Spatz disease, is a rare, life-threatening neurologic disorder that affects...

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Detalles Bibliográficos
Autores principales: Li, Yanan, Steinberg, Jeffrey, Coleman, Zane, Wang, Shubo, Subramanian, Chitra, Li, Yimei, Patay, Zoltan, Akers, Walter, Rock, Charles O., Jackowski, Suzanne, Bagga, Puneet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867880/
https://www.ncbi.nlm.nih.gov/pubmed/35197056
http://dx.doi.org/10.1186/s12967-022-03304-y

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