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Facing crises in the 21st century: microfluidics approaches for antibiotic discovery
We urgently need new antibiotics to counteract the rising in the emergence of multidrug‐resistant microorganisms. To improve the identification of antimicrobial compounds of microbial origin, numerous multidisciplinary approaches are being implemented. However, the development of innovative microbia...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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John Wiley and Sons Inc.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867967/ https://www.ncbi.nlm.nih.gov/pubmed/34333833 http://dx.doi.org/10.1111/1751-7915.13908 |
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author | Matilla, Miguel A. |
author_facet | Matilla, Miguel A. |
author_sort | Matilla, Miguel A. |
collection | PubMed |
description | We urgently need new antibiotics to counteract the rising in the emergence of multidrug‐resistant microorganisms. To improve the identification of antimicrobial compounds of microbial origin, numerous multidisciplinary approaches are being implemented. However, the development of innovative microbial cultivation strategies is necessary to exploit the full biosynthetic potential of non‐culturable microorganisms. Here, I highlight various articles that employ high‐throughput microfluidic‐based strategies to identify novel antimicrobial metabolites based on bacterial activities. The rapid development of this technology will likely advance the field of antibiotic discovery. |
format | Online Article Text |
id | pubmed-8867967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88679672022-02-28 Facing crises in the 21st century: microfluidics approaches for antibiotic discovery Matilla, Miguel A. Microb Biotechnol Highlight We urgently need new antibiotics to counteract the rising in the emergence of multidrug‐resistant microorganisms. To improve the identification of antimicrobial compounds of microbial origin, numerous multidisciplinary approaches are being implemented. However, the development of innovative microbial cultivation strategies is necessary to exploit the full biosynthetic potential of non‐culturable microorganisms. Here, I highlight various articles that employ high‐throughput microfluidic‐based strategies to identify novel antimicrobial metabolites based on bacterial activities. The rapid development of this technology will likely advance the field of antibiotic discovery. John Wiley and Sons Inc. 2021-08-01 /pmc/articles/PMC8867967/ /pubmed/34333833 http://dx.doi.org/10.1111/1751-7915.13908 Text en © 2021 The Authors. Microbial Biotechnology published by Society for Applied Microbiology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Highlight Matilla, Miguel A. Facing crises in the 21st century: microfluidics approaches for antibiotic discovery |
title | Facing crises in the 21st century: microfluidics approaches for antibiotic discovery |
title_full | Facing crises in the 21st century: microfluidics approaches for antibiotic discovery |
title_fullStr | Facing crises in the 21st century: microfluidics approaches for antibiotic discovery |
title_full_unstemmed | Facing crises in the 21st century: microfluidics approaches for antibiotic discovery |
title_short | Facing crises in the 21st century: microfluidics approaches for antibiotic discovery |
title_sort | facing crises in the 21st century: microfluidics approaches for antibiotic discovery |
topic | Highlight |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867967/ https://www.ncbi.nlm.nih.gov/pubmed/34333833 http://dx.doi.org/10.1111/1751-7915.13908 |
work_keys_str_mv | AT matillamiguela facingcrisesinthe21stcenturymicrofluidicsapproachesforantibioticdiscovery |