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Facing crises in the 21st century: microfluidics approaches for antibiotic discovery

We urgently need new antibiotics to counteract the rising in the emergence of multidrug‐resistant microorganisms. To improve the identification of antimicrobial compounds of microbial origin, numerous multidisciplinary approaches are being implemented. However, the development of innovative microbia...

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Detalles Bibliográficos
Autor principal: Matilla, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867967/
https://www.ncbi.nlm.nih.gov/pubmed/34333833
http://dx.doi.org/10.1111/1751-7915.13908
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author Matilla, Miguel A.
author_facet Matilla, Miguel A.
author_sort Matilla, Miguel A.
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description We urgently need new antibiotics to counteract the rising in the emergence of multidrug‐resistant microorganisms. To improve the identification of antimicrobial compounds of microbial origin, numerous multidisciplinary approaches are being implemented. However, the development of innovative microbial cultivation strategies is necessary to exploit the full biosynthetic potential of non‐culturable microorganisms. Here, I highlight various articles that employ high‐throughput microfluidic‐based strategies to identify novel antimicrobial metabolites based on bacterial activities. The rapid development of this technology will likely advance the field of antibiotic discovery.
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spelling pubmed-88679672022-02-28 Facing crises in the 21st century: microfluidics approaches for antibiotic discovery Matilla, Miguel A. Microb Biotechnol Highlight We urgently need new antibiotics to counteract the rising in the emergence of multidrug‐resistant microorganisms. To improve the identification of antimicrobial compounds of microbial origin, numerous multidisciplinary approaches are being implemented. However, the development of innovative microbial cultivation strategies is necessary to exploit the full biosynthetic potential of non‐culturable microorganisms. Here, I highlight various articles that employ high‐throughput microfluidic‐based strategies to identify novel antimicrobial metabolites based on bacterial activities. The rapid development of this technology will likely advance the field of antibiotic discovery. John Wiley and Sons Inc. 2021-08-01 /pmc/articles/PMC8867967/ /pubmed/34333833 http://dx.doi.org/10.1111/1751-7915.13908 Text en © 2021 The Authors. Microbial Biotechnology published by Society for Applied Microbiology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Highlight
Matilla, Miguel A.
Facing crises in the 21st century: microfluidics approaches for antibiotic discovery
title Facing crises in the 21st century: microfluidics approaches for antibiotic discovery
title_full Facing crises in the 21st century: microfluidics approaches for antibiotic discovery
title_fullStr Facing crises in the 21st century: microfluidics approaches for antibiotic discovery
title_full_unstemmed Facing crises in the 21st century: microfluidics approaches for antibiotic discovery
title_short Facing crises in the 21st century: microfluidics approaches for antibiotic discovery
title_sort facing crises in the 21st century: microfluidics approaches for antibiotic discovery
topic Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867967/
https://www.ncbi.nlm.nih.gov/pubmed/34333833
http://dx.doi.org/10.1111/1751-7915.13908
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