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Harpagoside Protects Against Doxorubicin-Induced Cardiotoxicity via P53-Parkin-Mediated Mitophagy

Doxorubicin (DOX) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe risk of cardiotoxicity. One of the hallmarks of doxorubicin-induced cardiotoxicity (DICT) is the cascade of mitophagy deficiency-mitochondrial oxidative injury-apoptosis, wh...

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Detalles Bibliográficos
Autores principales:	Li, Weili, Wang, Xiaoping, Liu, Tianhua, Zhang, Qian, Cao, Jing, Jiang, Yanyan, Sun, Qianbin, Li, Chun, Wang, Wei, Wang, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867983/ https://www.ncbi.nlm.nih.gov/pubmed/35223843 http://dx.doi.org/10.3389/fcell.2022.813370

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