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Serum Trace Elements Concentrations in Patients with Restless Legs Syndrome

Increased brain and serum zinc levels in patients with idiopathic restless legs syndrome (idiopathic RLS or iRLS) were described when compared with controls, suggesting a possible role of zinc in the pathogenesis of this disease. However, serum magnesium, calcium, manganese, iron, and copper levels...

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Autores principales: Jiménez-Jiménez, Félix Javier, Ayuso, Pedro, Alonso-Navarro, Hortensia, Calleja, Marisol, Díez-Fairén, Mónica, Álvarez, Ignacio, Pastor, Pau, Plaza-Nieto, José Francisco, Navarro-Muñoz, Santiago, Turpín-Fenoll, Laura, Millán-Pascual, Jorge, Recio-Bermejo, Marta, García-Ruiz, Rafael, García-Albea, Esteban, Agúndez, José A. G., García-Martín, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868060/
https://www.ncbi.nlm.nih.gov/pubmed/35204155
http://dx.doi.org/10.3390/antiox11020272
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author Jiménez-Jiménez, Félix Javier
Ayuso, Pedro
Alonso-Navarro, Hortensia
Calleja, Marisol
Díez-Fairén, Mónica
Álvarez, Ignacio
Pastor, Pau
Plaza-Nieto, José Francisco
Navarro-Muñoz, Santiago
Turpín-Fenoll, Laura
Millán-Pascual, Jorge
Recio-Bermejo, Marta
García-Ruiz, Rafael
García-Albea, Esteban
Agúndez, José A. G.
García-Martín, Elena
author_facet Jiménez-Jiménez, Félix Javier
Ayuso, Pedro
Alonso-Navarro, Hortensia
Calleja, Marisol
Díez-Fairén, Mónica
Álvarez, Ignacio
Pastor, Pau
Plaza-Nieto, José Francisco
Navarro-Muñoz, Santiago
Turpín-Fenoll, Laura
Millán-Pascual, Jorge
Recio-Bermejo, Marta
García-Ruiz, Rafael
García-Albea, Esteban
Agúndez, José A. G.
García-Martín, Elena
author_sort Jiménez-Jiménez, Félix Javier
collection PubMed
description Increased brain and serum zinc levels in patients with idiopathic restless legs syndrome (idiopathic RLS or iRLS) were described when compared with controls, suggesting a possible role of zinc in the pathogenesis of this disease. However, serum magnesium, calcium, manganese, iron, and copper levels of RLS patients were similar to controls, suggesting a specific impairment of zinc-dependent metabolism in RLS. The aim of this study is to assess the serum concentrations of trace elements involved in oxidative stress or causing peripheral nerve toxicity in a large series of patients with iRLS and controls. We determined serum levels of iron, copper, manganese, zinc, magnesium, selenium, calcium, aluminium, lead, cadmium, arsenic and mercury in 100 patients diagnosed with iRLS and in 110 age- and sex-matched controls using Inductively Coupled Plasma Mass Spectrometry. Serum copper, magnesium, selenium, and calcium concentrations were significantly higher in RLS patients than in controls. These differences were observed both in men and women. There were no major correlations between serum trace metal concentrations and age at onset of RLS or RLS severity, nor was there any association with a family history of RLS or drug response. This study shows an association between increased serum concentrations of copper, magnesium, selenium, and calcium with RLS in a Spanish Caucasian population and does not confirm the previously reported increase in serum zinc concentrations in patients suffering from this disease, suggesting that the different accuracy of the analytical methods used could have influenced the inconsistent results found in the literature.
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spelling pubmed-88680602022-02-25 Serum Trace Elements Concentrations in Patients with Restless Legs Syndrome Jiménez-Jiménez, Félix Javier Ayuso, Pedro Alonso-Navarro, Hortensia Calleja, Marisol Díez-Fairén, Mónica Álvarez, Ignacio Pastor, Pau Plaza-Nieto, José Francisco Navarro-Muñoz, Santiago Turpín-Fenoll, Laura Millán-Pascual, Jorge Recio-Bermejo, Marta García-Ruiz, Rafael García-Albea, Esteban Agúndez, José A. G. García-Martín, Elena Antioxidants (Basel) Article Increased brain and serum zinc levels in patients with idiopathic restless legs syndrome (idiopathic RLS or iRLS) were described when compared with controls, suggesting a possible role of zinc in the pathogenesis of this disease. However, serum magnesium, calcium, manganese, iron, and copper levels of RLS patients were similar to controls, suggesting a specific impairment of zinc-dependent metabolism in RLS. The aim of this study is to assess the serum concentrations of trace elements involved in oxidative stress or causing peripheral nerve toxicity in a large series of patients with iRLS and controls. We determined serum levels of iron, copper, manganese, zinc, magnesium, selenium, calcium, aluminium, lead, cadmium, arsenic and mercury in 100 patients diagnosed with iRLS and in 110 age- and sex-matched controls using Inductively Coupled Plasma Mass Spectrometry. Serum copper, magnesium, selenium, and calcium concentrations were significantly higher in RLS patients than in controls. These differences were observed both in men and women. There were no major correlations between serum trace metal concentrations and age at onset of RLS or RLS severity, nor was there any association with a family history of RLS or drug response. This study shows an association between increased serum concentrations of copper, magnesium, selenium, and calcium with RLS in a Spanish Caucasian population and does not confirm the previously reported increase in serum zinc concentrations in patients suffering from this disease, suggesting that the different accuracy of the analytical methods used could have influenced the inconsistent results found in the literature. MDPI 2022-01-29 /pmc/articles/PMC8868060/ /pubmed/35204155 http://dx.doi.org/10.3390/antiox11020272 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jiménez-Jiménez, Félix Javier
Ayuso, Pedro
Alonso-Navarro, Hortensia
Calleja, Marisol
Díez-Fairén, Mónica
Álvarez, Ignacio
Pastor, Pau
Plaza-Nieto, José Francisco
Navarro-Muñoz, Santiago
Turpín-Fenoll, Laura
Millán-Pascual, Jorge
Recio-Bermejo, Marta
García-Ruiz, Rafael
García-Albea, Esteban
Agúndez, José A. G.
García-Martín, Elena
Serum Trace Elements Concentrations in Patients with Restless Legs Syndrome
title Serum Trace Elements Concentrations in Patients with Restless Legs Syndrome
title_full Serum Trace Elements Concentrations in Patients with Restless Legs Syndrome
title_fullStr Serum Trace Elements Concentrations in Patients with Restless Legs Syndrome
title_full_unstemmed Serum Trace Elements Concentrations in Patients with Restless Legs Syndrome
title_short Serum Trace Elements Concentrations in Patients with Restless Legs Syndrome
title_sort serum trace elements concentrations in patients with restless legs syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868060/
https://www.ncbi.nlm.nih.gov/pubmed/35204155
http://dx.doi.org/10.3390/antiox11020272
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