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Computational Analysis of Histone Deacetylase 10 Mechanism by the ONIOM Method: A Complementary Approach to X-ray and Kinetics Studies

[Image: see text] Histone deacetylase 10 (HDAC 10) catalyzes deacetylation of N(8)-acetylspermidine into spermidine in the cytosolic region of eukaryotic cells. Inhibition of HDAC 10 has clinical importance in certain types of cancers. Recently, X-ray crystal structures corresponding to the substrat...

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Detalles Bibliográficos
Autores principales:	Yildiz, Ibrahim, Yildiz, Banu Sizirici
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868106/ https://www.ncbi.nlm.nih.gov/pubmed/35224400 http://dx.doi.org/10.1021/acsomega.1c07055

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