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Trapping of 5-Fluorodeoxyuridine Monophosphate by Thymidylate Synthase Confers Resistance to 5-Fluorouracil

[Image: see text] The major metabolite of the anticancer agent 5-fluorouracil (5-FU) is 5-fluorodeoxyuridine monophosphate (FdUMP), which is a potent inhibitor of thymidylate synthase (TS). Recently, we hypothesized that 5-FU-resistant colorectal cancer (CRC) cells have increased levels of TS protei...

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Detalles Bibliográficos
Autores principales:	Kurasaka, Chinatsu, Nishizawa, Nana, Ogino, Yoko, Sato, Akira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868108/ https://www.ncbi.nlm.nih.gov/pubmed/35224365 http://dx.doi.org/10.1021/acsomega.1c06394

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