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The Predictive Value of Dynamic Intrinsic Local Metrics in Transient Ischemic Attack
BACKGROUND: Transient ischemic attack (TIA) is known as “small stroke.” However, the diagnosis of TIA is currently difficult due to the transient symptoms. Therefore, objective and reliable biomarkers are urgently needed in clinical practice. OBJECTIVE: The purpose of this study was to investigate w...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868122/ https://www.ncbi.nlm.nih.gov/pubmed/35221984 http://dx.doi.org/10.3389/fnagi.2021.808094 |
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author | Ma, Huibin Huang, Guofeng Li, Mengting Han, Yu Sun, Jiawei Zhan, Linlin Wang, Qianqian Jia, Xize Han, Xiujie Li, Huayun Song, Yulin Lv, Yating |
author_facet | Ma, Huibin Huang, Guofeng Li, Mengting Han, Yu Sun, Jiawei Zhan, Linlin Wang, Qianqian Jia, Xize Han, Xiujie Li, Huayun Song, Yulin Lv, Yating |
author_sort | Ma, Huibin |
collection | PubMed |
description | BACKGROUND: Transient ischemic attack (TIA) is known as “small stroke.” However, the diagnosis of TIA is currently difficult due to the transient symptoms. Therefore, objective and reliable biomarkers are urgently needed in clinical practice. OBJECTIVE: The purpose of this study was to investigate whether dynamic alterations in resting-state local metrics could differentiate patients with TIA from healthy controls (HCs) using the support-vector machine (SVM) classification method. METHODS: By analyzing resting-state functional MRI (rs-fMRI) data from 48 patients with and 41 demographically matched HCs, we compared the group differences in three dynamic local metrics: dynamic amplitude of low-frequency fluctuation (d-ALFF), dynamic fractional amplitude of low-frequency fluctuation (d-fALFF), and dynamic regional homogeneity (d-ReHo). Furthermore, we selected the observed alterations in three dynamic local metrics as classification features to distinguish patients with TIA from HCs through SVM classifier. RESULTS: We found that TIA was associated with disruptions in dynamic local intrinsic brain activities. Compared with HCs, the patients with TIA exhibited increased d-fALFF, d-fALFF, and d-ReHo in vermis, right calcarine, right middle temporal gyrus, opercular part of right inferior frontal gyrus, left calcarine, left occipital, and left temporal and cerebellum. These alternations in the dynamic local metrics exhibited an accuracy of 80.90%, sensitivity of 77.08%, specificity of 85.37%, precision of 86.05%, and area under curve of 0.8501 for distinguishing the patients from HCs. CONCLUSION: Our findings may provide important evidence for understanding the neuropathology underlying TIA and strong support for the hypothesis that these local metrics have potential value in clinical diagnosis. |
format | Online Article Text |
id | pubmed-8868122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88681222022-02-25 The Predictive Value of Dynamic Intrinsic Local Metrics in Transient Ischemic Attack Ma, Huibin Huang, Guofeng Li, Mengting Han, Yu Sun, Jiawei Zhan, Linlin Wang, Qianqian Jia, Xize Han, Xiujie Li, Huayun Song, Yulin Lv, Yating Front Aging Neurosci Aging Neuroscience BACKGROUND: Transient ischemic attack (TIA) is known as “small stroke.” However, the diagnosis of TIA is currently difficult due to the transient symptoms. Therefore, objective and reliable biomarkers are urgently needed in clinical practice. OBJECTIVE: The purpose of this study was to investigate whether dynamic alterations in resting-state local metrics could differentiate patients with TIA from healthy controls (HCs) using the support-vector machine (SVM) classification method. METHODS: By analyzing resting-state functional MRI (rs-fMRI) data from 48 patients with and 41 demographically matched HCs, we compared the group differences in three dynamic local metrics: dynamic amplitude of low-frequency fluctuation (d-ALFF), dynamic fractional amplitude of low-frequency fluctuation (d-fALFF), and dynamic regional homogeneity (d-ReHo). Furthermore, we selected the observed alterations in three dynamic local metrics as classification features to distinguish patients with TIA from HCs through SVM classifier. RESULTS: We found that TIA was associated with disruptions in dynamic local intrinsic brain activities. Compared with HCs, the patients with TIA exhibited increased d-fALFF, d-fALFF, and d-ReHo in vermis, right calcarine, right middle temporal gyrus, opercular part of right inferior frontal gyrus, left calcarine, left occipital, and left temporal and cerebellum. These alternations in the dynamic local metrics exhibited an accuracy of 80.90%, sensitivity of 77.08%, specificity of 85.37%, precision of 86.05%, and area under curve of 0.8501 for distinguishing the patients from HCs. CONCLUSION: Our findings may provide important evidence for understanding the neuropathology underlying TIA and strong support for the hypothesis that these local metrics have potential value in clinical diagnosis. Frontiers Media S.A. 2022-02-10 /pmc/articles/PMC8868122/ /pubmed/35221984 http://dx.doi.org/10.3389/fnagi.2021.808094 Text en Copyright © 2022 Ma, Huang, Li, Han, Sun, Zhan, Wang, Jia, Han, Li, Song and Lv. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Aging Neuroscience Ma, Huibin Huang, Guofeng Li, Mengting Han, Yu Sun, Jiawei Zhan, Linlin Wang, Qianqian Jia, Xize Han, Xiujie Li, Huayun Song, Yulin Lv, Yating The Predictive Value of Dynamic Intrinsic Local Metrics in Transient Ischemic Attack |
title | The Predictive Value of Dynamic Intrinsic Local Metrics in Transient Ischemic Attack |
title_full | The Predictive Value of Dynamic Intrinsic Local Metrics in Transient Ischemic Attack |
title_fullStr | The Predictive Value of Dynamic Intrinsic Local Metrics in Transient Ischemic Attack |
title_full_unstemmed | The Predictive Value of Dynamic Intrinsic Local Metrics in Transient Ischemic Attack |
title_short | The Predictive Value of Dynamic Intrinsic Local Metrics in Transient Ischemic Attack |
title_sort | predictive value of dynamic intrinsic local metrics in transient ischemic attack |
topic | Aging Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868122/ https://www.ncbi.nlm.nih.gov/pubmed/35221984 http://dx.doi.org/10.3389/fnagi.2021.808094 |
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