Enhanced Cardiac CaMKII Oxidation and CaMKII-Dependent SR Ca Leak in Patients with Sleep-Disordered Breathing

Background: Sleep-disordered breathing (SDB) is associated with increased oxidant generation. Oxidized Ca/calmodulin kinase II (CaMKII) can contribute to atrial arrhythmias by the stimulation of sarcoplasmic reticulum Ca release events, i.e., Ca sparks. Methods: We prospectively enrolled 39 patients...

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Detalles Bibliográficos
Autores principales: Arzt, Michael, Drzymalski, Marzena A., Ripfel, Sarah, Meindl, Sebastian, Biedermann, Alexander, Durczok, Melanie, Keller, Karoline, Mustroph, Julian, Katz, Sylvia, Tafelmeier, Maria, Lebek, Simon, Flörchinger, Bernhard, Camboni, Daniele, Wittmann, Sigrid, Backs, Johannes, Schmid, Christof, Maier, Lars S., Wagner, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868143/
https://www.ncbi.nlm.nih.gov/pubmed/35204213
http://dx.doi.org/10.3390/antiox11020331

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