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New Antibacterial Secondary Metabolites from a Marine-Derived Talaromyces sp. Strain BTBU20213036

New polyketide-derived oligophenalenone dimers, bacillisporins K and L (1 and 2) and xanthoradone dimer rugulosin D (3), together with four known compounds, bacillisporin B (4), macrosporusone D (5), rugulosin A and penicillide (6 and 7), were isolated from the marine-derived fungus Talaromyces sp....

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Detalles Bibliográficos
Autores principales: Song, Fuhang, Dong, Yifei, Wei, Shangzhu, Zhang, Xinwan, Zhang, Kai, Xu, Xiuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868179/
https://www.ncbi.nlm.nih.gov/pubmed/35203824
http://dx.doi.org/10.3390/antibiotics11020222
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author Song, Fuhang
Dong, Yifei
Wei, Shangzhu
Zhang, Xinwan
Zhang, Kai
Xu, Xiuli
author_facet Song, Fuhang
Dong, Yifei
Wei, Shangzhu
Zhang, Xinwan
Zhang, Kai
Xu, Xiuli
author_sort Song, Fuhang
collection PubMed
description New polyketide-derived oligophenalenone dimers, bacillisporins K and L (1 and 2) and xanthoradone dimer rugulosin D (3), together with four known compounds, bacillisporin B (4), macrosporusone D (5), rugulosin A and penicillide (6 and 7), were isolated from the marine-derived fungus Talaromyces sp. BTBU20213036. Their structures were determined by detailed analysis of HRESIMS, 1D and 2D NMR data, and the absolute configurations were determined on the basis of calculated and experimental electronic circular dichroism (ECD). The antibacterial and antifungal activities of these compounds were tested against Gram-positive—Staphylococcus aureus, Gram-negative—Escherichia coli, and fungal strain—Candida albicans. These compounds showed potential inhibitory effects against S. aureus with minimum inhibitory concentrations ranging from 0.195 to 100 µg/mL.
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spelling pubmed-88681792022-02-25 New Antibacterial Secondary Metabolites from a Marine-Derived Talaromyces sp. Strain BTBU20213036 Song, Fuhang Dong, Yifei Wei, Shangzhu Zhang, Xinwan Zhang, Kai Xu, Xiuli Antibiotics (Basel) Article New polyketide-derived oligophenalenone dimers, bacillisporins K and L (1 and 2) and xanthoradone dimer rugulosin D (3), together with four known compounds, bacillisporin B (4), macrosporusone D (5), rugulosin A and penicillide (6 and 7), were isolated from the marine-derived fungus Talaromyces sp. BTBU20213036. Their structures were determined by detailed analysis of HRESIMS, 1D and 2D NMR data, and the absolute configurations were determined on the basis of calculated and experimental electronic circular dichroism (ECD). The antibacterial and antifungal activities of these compounds were tested against Gram-positive—Staphylococcus aureus, Gram-negative—Escherichia coli, and fungal strain—Candida albicans. These compounds showed potential inhibitory effects against S. aureus with minimum inhibitory concentrations ranging from 0.195 to 100 µg/mL. MDPI 2022-02-10 /pmc/articles/PMC8868179/ /pubmed/35203824 http://dx.doi.org/10.3390/antibiotics11020222 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Song, Fuhang
Dong, Yifei
Wei, Shangzhu
Zhang, Xinwan
Zhang, Kai
Xu, Xiuli
New Antibacterial Secondary Metabolites from a Marine-Derived Talaromyces sp. Strain BTBU20213036
title New Antibacterial Secondary Metabolites from a Marine-Derived Talaromyces sp. Strain BTBU20213036
title_full New Antibacterial Secondary Metabolites from a Marine-Derived Talaromyces sp. Strain BTBU20213036
title_fullStr New Antibacterial Secondary Metabolites from a Marine-Derived Talaromyces sp. Strain BTBU20213036
title_full_unstemmed New Antibacterial Secondary Metabolites from a Marine-Derived Talaromyces sp. Strain BTBU20213036
title_short New Antibacterial Secondary Metabolites from a Marine-Derived Talaromyces sp. Strain BTBU20213036
title_sort new antibacterial secondary metabolites from a marine-derived talaromyces sp. strain btbu20213036
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868179/
https://www.ncbi.nlm.nih.gov/pubmed/35203824
http://dx.doi.org/10.3390/antibiotics11020222
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