Naturally Occurring Endocrine Disorders in Non-Human Primates: A Comprehensive Review

SIMPLE SUMMARY: Nonhuman primates (NHP) can become ill due to a variety of diseases and disorders, yet endocrine disorders remain underreported. Therefore, an exhaustive literature search on this subject via widely used academic search systems, peer-reviewed publications, proceedings, and newsletters was performed. Selected major endocrine entities will be described emphasizing clinical signs, morphologic features, concomitant diseases, as well as available treatment options. In most cases, no clinical signs were noted and on gross pathology, the endocrine organs were unremarkable. The diagnosis was frequently made as incidental findings after standard histological examination. Although the findings were frequently incidental many have the potential to impact studies. This review explains that there is no standard procedure for diagnosing, monitoring, or treating endocrine disorders in NHP. More research is needed to evaluate these procedures and establish risk factors. ABSTRACT: Literature concerning veterinary medicine of non-human primates is continuously updated, yet endocrine disorders remain underreported. While case or survey reports of individual endocrinopathies are available, a comprehensive review is not. An exhaustive literature search on this subject via widely used academic search systems, (e.g., Google Scholar, PubMed, BioOne complete and Web of Science), and peer-reviewed publications, proceedings, and newsletters was performed. Selected major endocrine entities will be described with emphasis on clinical signs, morphologic appearances, concomitant diseases, as well as available treatment options. Mostly, no clinical signs were noted and on gross pathology, the endocrine organs were unremarkable. An endocrine-related diagnosis was frequently made as an incidental finding after standard histopathological examination. During the review, the pancreas represented the most affected endocrine organ and diabetes mellitus represented the most clinically significant disorder. Currently, no standard procedure for diagnosing, monitoring, or treating endocrine disorders in non-human primates exists.