Cargando…

COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment

COVID-19 has reached pandemic proportions worldwide, with considerable consequences for both health and the economy. In pregnant women, COVID-19 can alter the metabolic environment, iron metabolism, and oxygen supply of trophoblastic cells, and therefore have a negative influence on essential mechan...

Descripción completa

Detalles Bibliográficos
Autores principales: Moreno-Fernandez, Jorge, Ochoa, Julio J., De Paco Matallana, Catalina, Caño, Africa, Martín-Alvarez, Estefania, Sanchez-Romero, Javier, Toledano, Juan M., Puche-Juarez, Maria, Prados, Sonia, Ruiz-Duran, Susana, Diaz-Meca, Lucia, Carrillo, María Paz, Diaz-Castro, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868249/
https://www.ncbi.nlm.nih.gov/pubmed/35204067
http://dx.doi.org/10.3390/antiox11020184
_version_ 1784656222186635264
author Moreno-Fernandez, Jorge
Ochoa, Julio J.
De Paco Matallana, Catalina
Caño, Africa
Martín-Alvarez, Estefania
Sanchez-Romero, Javier
Toledano, Juan M.
Puche-Juarez, Maria
Prados, Sonia
Ruiz-Duran, Susana
Diaz-Meca, Lucia
Carrillo, María Paz
Diaz-Castro, Javier
author_facet Moreno-Fernandez, Jorge
Ochoa, Julio J.
De Paco Matallana, Catalina
Caño, Africa
Martín-Alvarez, Estefania
Sanchez-Romero, Javier
Toledano, Juan M.
Puche-Juarez, Maria
Prados, Sonia
Ruiz-Duran, Susana
Diaz-Meca, Lucia
Carrillo, María Paz
Diaz-Castro, Javier
author_sort Moreno-Fernandez, Jorge
collection PubMed
description COVID-19 has reached pandemic proportions worldwide, with considerable consequences for both health and the economy. In pregnant women, COVID-19 can alter the metabolic environment, iron metabolism, and oxygen supply of trophoblastic cells, and therefore have a negative influence on essential mechanisms of fetal development. The purpose of this study was to investigate, for the first time, the effects of COVID-19 infection during pregnancy with regard to the oxidative/antioxidant status in mothers’ serum and placenta, together with placental iron metabolism. Results showed no differences in superoxide dismutase activity and placental antioxidant capacity. However, antioxidant capacity decreased in the serum of infected mothers. Catalase activity decreased in the COVID-19 group, while an increase in 8-hydroxy-2’-deoxyguanosine, hydroperoxides, 15-FT-isoprostanes, and carbonyl groups were recorded in this group. Placental vitamin D, E, and Coenzyme-Q10 also showed to be increased in the COVID-19 group. As for iron-related proteins, an up-regulation of placental DMT1, ferroportin-1, and ferritin expression was recorded in infected women. Due to the potential role of iron metabolism and oxidative stress in placental function and complications, further research is needed to explain the pathogenic mechanism of COVID-19 that may affect pregnancy, so as to assess the short-term and long-term outcomes in mothers’ and infants’ health.
format Online
Article
Text
id pubmed-8868249
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88682492022-02-25 COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment Moreno-Fernandez, Jorge Ochoa, Julio J. De Paco Matallana, Catalina Caño, Africa Martín-Alvarez, Estefania Sanchez-Romero, Javier Toledano, Juan M. Puche-Juarez, Maria Prados, Sonia Ruiz-Duran, Susana Diaz-Meca, Lucia Carrillo, María Paz Diaz-Castro, Javier Antioxidants (Basel) Article COVID-19 has reached pandemic proportions worldwide, with considerable consequences for both health and the economy. In pregnant women, COVID-19 can alter the metabolic environment, iron metabolism, and oxygen supply of trophoblastic cells, and therefore have a negative influence on essential mechanisms of fetal development. The purpose of this study was to investigate, for the first time, the effects of COVID-19 infection during pregnancy with regard to the oxidative/antioxidant status in mothers’ serum and placenta, together with placental iron metabolism. Results showed no differences in superoxide dismutase activity and placental antioxidant capacity. However, antioxidant capacity decreased in the serum of infected mothers. Catalase activity decreased in the COVID-19 group, while an increase in 8-hydroxy-2’-deoxyguanosine, hydroperoxides, 15-FT-isoprostanes, and carbonyl groups were recorded in this group. Placental vitamin D, E, and Coenzyme-Q10 also showed to be increased in the COVID-19 group. As for iron-related proteins, an up-regulation of placental DMT1, ferroportin-1, and ferritin expression was recorded in infected women. Due to the potential role of iron metabolism and oxidative stress in placental function and complications, further research is needed to explain the pathogenic mechanism of COVID-19 that may affect pregnancy, so as to assess the short-term and long-term outcomes in mothers’ and infants’ health. MDPI 2022-01-18 /pmc/articles/PMC8868249/ /pubmed/35204067 http://dx.doi.org/10.3390/antiox11020184 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moreno-Fernandez, Jorge
Ochoa, Julio J.
De Paco Matallana, Catalina
Caño, Africa
Martín-Alvarez, Estefania
Sanchez-Romero, Javier
Toledano, Juan M.
Puche-Juarez, Maria
Prados, Sonia
Ruiz-Duran, Susana
Diaz-Meca, Lucia
Carrillo, María Paz
Diaz-Castro, Javier
COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment
title COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment
title_full COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment
title_fullStr COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment
title_full_unstemmed COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment
title_short COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment
title_sort covid-19 during gestation: maternal implications of evoked oxidative stress and iron metabolism impairment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868249/
https://www.ncbi.nlm.nih.gov/pubmed/35204067
http://dx.doi.org/10.3390/antiox11020184
work_keys_str_mv AT morenofernandezjorge covid19duringgestationmaternalimplicationsofevokedoxidativestressandironmetabolismimpairment
AT ochoajulioj covid19duringgestationmaternalimplicationsofevokedoxidativestressandironmetabolismimpairment
AT depacomatallanacatalina covid19duringgestationmaternalimplicationsofevokedoxidativestressandironmetabolismimpairment
AT canoafrica covid19duringgestationmaternalimplicationsofevokedoxidativestressandironmetabolismimpairment
AT martinalvarezestefania covid19duringgestationmaternalimplicationsofevokedoxidativestressandironmetabolismimpairment
AT sanchezromerojavier covid19duringgestationmaternalimplicationsofevokedoxidativestressandironmetabolismimpairment
AT toledanojuanm covid19duringgestationmaternalimplicationsofevokedoxidativestressandironmetabolismimpairment
AT puchejuarezmaria covid19duringgestationmaternalimplicationsofevokedoxidativestressandironmetabolismimpairment
AT pradossonia covid19duringgestationmaternalimplicationsofevokedoxidativestressandironmetabolismimpairment
AT ruizduransusana covid19duringgestationmaternalimplicationsofevokedoxidativestressandironmetabolismimpairment
AT diazmecalucia covid19duringgestationmaternalimplicationsofevokedoxidativestressandironmetabolismimpairment
AT carrillomariapaz covid19duringgestationmaternalimplicationsofevokedoxidativestressandironmetabolismimpairment
AT diazcastrojavier covid19duringgestationmaternalimplicationsofevokedoxidativestressandironmetabolismimpairment