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Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease—A Retrospective, Case-Control Pilot Study

Fetuses with congenital heart disease (CHD) have circulatory changes that may lead to predictable blood flow disturbances that may affect normal brain development. Hypoxemia and hypoperfusion may alter the redox balance leading to oxidative stress (OS), that can be assessed measuring stable end-prod...

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Autores principales: Escobar-Diaz, Maria C., Pérez-Cruz, Miriam, Arráez, Miguel, Cascant-Vilaplana, Mari-Merce, Albiach-Delgado, Abel, Kuligowski, Julia, Vento, Máximo, Masoller, Narcis, Gómez-Roig, Maria Dolores, Gómez, Olga, Sanchez-de-Toledo, Joan, Camprubí-Camprubí, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868271/
https://www.ncbi.nlm.nih.gov/pubmed/35204182
http://dx.doi.org/10.3390/antiox11020299
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author Escobar-Diaz, Maria C.
Pérez-Cruz, Miriam
Arráez, Miguel
Cascant-Vilaplana, Mari-Merce
Albiach-Delgado, Abel
Kuligowski, Julia
Vento, Máximo
Masoller, Narcis
Gómez-Roig, Maria Dolores
Gómez, Olga
Sanchez-de-Toledo, Joan
Camprubí-Camprubí, Marta
author_facet Escobar-Diaz, Maria C.
Pérez-Cruz, Miriam
Arráez, Miguel
Cascant-Vilaplana, Mari-Merce
Albiach-Delgado, Abel
Kuligowski, Julia
Vento, Máximo
Masoller, Narcis
Gómez-Roig, Maria Dolores
Gómez, Olga
Sanchez-de-Toledo, Joan
Camprubí-Camprubí, Marta
author_sort Escobar-Diaz, Maria C.
collection PubMed
description Fetuses with congenital heart disease (CHD) have circulatory changes that may lead to predictable blood flow disturbances that may affect normal brain development. Hypoxemia and hypoperfusion may alter the redox balance leading to oxidative stress (OS), that can be assessed measuring stable end-products. OS biomarkers (OSB) were measured in amniotic fluid in fetuses with (n = 41) and without CHD (n = 44) and analyzed according to aortic flow, expected cyanosis after birth, and a CHD classification derived from this. Birth head circumference (HC) was used as a neurodevelopment biomarker. CHD fetuses had higher levels of ortho-Tyrosine (o-Tyr) than controls (p = 0.0003). There were no differences in o-Tyr levels considering aortic flow obstruction (p = 0.617). Fetuses with expected extreme cyanosis presented the highest levels of o-Tyr (p = 0.003). Among groups of CHD, fetuses without aortic obstruction and extreme cyanosis had the highest levels of o-Tyr (p = 0.005). CHD patients had lower HC than controls (p = 0.023), without correlation with OSB. Patients with HC < 10th percentile, presented high levels of o-Tyr (p = 0.024). Fetuses with CHD showed increased OSB and lower HC when compared to controls, especially those with expected extreme cyanosis. Our results suggest that increased levels of OSB are more influenced by the effect of low oxygenation than by aortic flow obstruction. Future studies with larger sample size are needed to further investigate the role of OSB as an early predictor of neurodevelopmental problems in CHD survivors.
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spelling pubmed-88682712022-02-25 Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease—A Retrospective, Case-Control Pilot Study Escobar-Diaz, Maria C. Pérez-Cruz, Miriam Arráez, Miguel Cascant-Vilaplana, Mari-Merce Albiach-Delgado, Abel Kuligowski, Julia Vento, Máximo Masoller, Narcis Gómez-Roig, Maria Dolores Gómez, Olga Sanchez-de-Toledo, Joan Camprubí-Camprubí, Marta Antioxidants (Basel) Article Fetuses with congenital heart disease (CHD) have circulatory changes that may lead to predictable blood flow disturbances that may affect normal brain development. Hypoxemia and hypoperfusion may alter the redox balance leading to oxidative stress (OS), that can be assessed measuring stable end-products. OS biomarkers (OSB) were measured in amniotic fluid in fetuses with (n = 41) and without CHD (n = 44) and analyzed according to aortic flow, expected cyanosis after birth, and a CHD classification derived from this. Birth head circumference (HC) was used as a neurodevelopment biomarker. CHD fetuses had higher levels of ortho-Tyrosine (o-Tyr) than controls (p = 0.0003). There were no differences in o-Tyr levels considering aortic flow obstruction (p = 0.617). Fetuses with expected extreme cyanosis presented the highest levels of o-Tyr (p = 0.003). Among groups of CHD, fetuses without aortic obstruction and extreme cyanosis had the highest levels of o-Tyr (p = 0.005). CHD patients had lower HC than controls (p = 0.023), without correlation with OSB. Patients with HC < 10th percentile, presented high levels of o-Tyr (p = 0.024). Fetuses with CHD showed increased OSB and lower HC when compared to controls, especially those with expected extreme cyanosis. Our results suggest that increased levels of OSB are more influenced by the effect of low oxygenation than by aortic flow obstruction. Future studies with larger sample size are needed to further investigate the role of OSB as an early predictor of neurodevelopmental problems in CHD survivors. MDPI 2022-01-31 /pmc/articles/PMC8868271/ /pubmed/35204182 http://dx.doi.org/10.3390/antiox11020299 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Escobar-Diaz, Maria C.
Pérez-Cruz, Miriam
Arráez, Miguel
Cascant-Vilaplana, Mari-Merce
Albiach-Delgado, Abel
Kuligowski, Julia
Vento, Máximo
Masoller, Narcis
Gómez-Roig, Maria Dolores
Gómez, Olga
Sanchez-de-Toledo, Joan
Camprubí-Camprubí, Marta
Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease—A Retrospective, Case-Control Pilot Study
title Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease—A Retrospective, Case-Control Pilot Study
title_full Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease—A Retrospective, Case-Control Pilot Study
title_fullStr Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease—A Retrospective, Case-Control Pilot Study
title_full_unstemmed Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease—A Retrospective, Case-Control Pilot Study
title_short Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease—A Retrospective, Case-Control Pilot Study
title_sort brain oxygen perfusion and oxidative stress biomarkers in fetuses with congenital heart disease—a retrospective, case-control pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868271/
https://www.ncbi.nlm.nih.gov/pubmed/35204182
http://dx.doi.org/10.3390/antiox11020299
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