Synthesis of Alkyne-Substituted Dihydropyrrolones as Bacterial Quorum-Sensing Inhibitors of Pseudomonas aeruginosa

The Quorum-sensing system in Pseudomonas aeruginosa is responsible for the pathogenicity and the production of virulence factors and biofilm formation. Dihydropyrrolones were previously found to act as inhibitors of QS-dependent bacterial phenotypes. In this study, a range of dihydropyrrolone (DHP)...

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Detalles Bibliográficos
Autores principales: Almohaywi, Basmah, Yu, Tsz Tin, Iskander, George, Sabir, Shekh, Bhadbhade, Mohan, Black, David StC., Kumar, Naresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868272/
https://www.ncbi.nlm.nih.gov/pubmed/35203755
http://dx.doi.org/10.3390/antibiotics11020151

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