Pharmacological Inhibition of Epac1 Averts Ferroptosis Cell Death by Preserving Mitochondrial Integrity

Exchange proteins directly activated by cAMP (Epac) proteins are implicated in a wide range of cellular functions including oxidative stress and cell survival. Mitochondrial-dependent oxidative stress has been associated with progressive neuronal death underlying the pathology of many neurodegenerat...

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Detalles Bibliográficos
Autores principales: Musheshe, Nshunge, Oun, Asmaa, Sabogal-Guáqueta, Angélica María, Trombetta-Lima, Marina, Mitchel, Sarah C., Adzemovic, Ahmed, Speek, Oliver, Morra, Francesca, van der Veen, Christina H. J. T., Lezoualc’h, Frank, Cheng, Xiaodong, Schmidt, Martina, Dolga, Amalia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868285/
https://www.ncbi.nlm.nih.gov/pubmed/35204198
http://dx.doi.org/10.3390/antiox11020314

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