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Oxidative Stress Evaluation in Dogs Affected with Canine Monocytic Ehrlichiosis

The study aimed to evaluate the concentration of reactive oxidative metabolites (R-OOHs), the antioxidant barrier (OXY), and the ratio between R-OOHs and OXY (OSi) and thiol groups of plasma compounds (SHp) in in canine monocytic ehrlichiosis. Thirty dogs affected with monocytic ehrlichiosis (canine...

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Autores principales: Pugliese, Michela, Biondi, Vito, Merola, Giordana, Landi, Alessandra, Passantino, Annamaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868293/
https://www.ncbi.nlm.nih.gov/pubmed/35204210
http://dx.doi.org/10.3390/antiox11020328
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author Pugliese, Michela
Biondi, Vito
Merola, Giordana
Landi, Alessandra
Passantino, Annamaria
author_facet Pugliese, Michela
Biondi, Vito
Merola, Giordana
Landi, Alessandra
Passantino, Annamaria
author_sort Pugliese, Michela
collection PubMed
description The study aimed to evaluate the concentration of reactive oxidative metabolites (R-OOHs), the antioxidant barrier (OXY), and the ratio between R-OOHs and OXY (OSi) and thiol groups of plasma compounds (SHp) in in canine monocytic ehrlichiosis. Thirty dogs affected with monocytic ehrlichiosis (canine monocytic ehrlichiosis group—CME group) and ten healthy dogs (control group—CTR group) were evaluated. CME was diagnosed by the presence of clinical signs and the detection of anti-Ehlichia canis antibodies. Oxidative stress parameters of two groups were compared using the Mann–Whitney test. Significance was set at p < 0.05. Spearman rank correlation was performed to analyze oxidative stress, and hematological and biochemical variables in the CME group. All dogs affected with CME showed a wide spectrum of clinical signs such as lethargy, anorexia, fever, weight loss, lymph adenomegaly, splenomegaly, subcutaneous and mucosal petechial and ecchymosis, and vomiting. Anaemia, leukocytosis, thrombocytopenia, hyperglobulinemia, hypoalbuminemia and an increase of blood urea nitrogen and creatinine are also detected. Results showed significantly lower values of SHp in the CME group than in CTR. A statistically significant difference in the number of white blood cells, platelets, and blood urea nitrogen concentration was assayed comparing to the two groups. A negative correlation between SHp and hemoglobin concentration was recorded. These preliminary results may suggest a possible function of oxidative stress in the onset of clinical signs during the course of CME.
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spelling pubmed-88682932022-02-25 Oxidative Stress Evaluation in Dogs Affected with Canine Monocytic Ehrlichiosis Pugliese, Michela Biondi, Vito Merola, Giordana Landi, Alessandra Passantino, Annamaria Antioxidants (Basel) Article The study aimed to evaluate the concentration of reactive oxidative metabolites (R-OOHs), the antioxidant barrier (OXY), and the ratio between R-OOHs and OXY (OSi) and thiol groups of plasma compounds (SHp) in in canine monocytic ehrlichiosis. Thirty dogs affected with monocytic ehrlichiosis (canine monocytic ehrlichiosis group—CME group) and ten healthy dogs (control group—CTR group) were evaluated. CME was diagnosed by the presence of clinical signs and the detection of anti-Ehlichia canis antibodies. Oxidative stress parameters of two groups were compared using the Mann–Whitney test. Significance was set at p < 0.05. Spearman rank correlation was performed to analyze oxidative stress, and hematological and biochemical variables in the CME group. All dogs affected with CME showed a wide spectrum of clinical signs such as lethargy, anorexia, fever, weight loss, lymph adenomegaly, splenomegaly, subcutaneous and mucosal petechial and ecchymosis, and vomiting. Anaemia, leukocytosis, thrombocytopenia, hyperglobulinemia, hypoalbuminemia and an increase of blood urea nitrogen and creatinine are also detected. Results showed significantly lower values of SHp in the CME group than in CTR. A statistically significant difference in the number of white blood cells, platelets, and blood urea nitrogen concentration was assayed comparing to the two groups. A negative correlation between SHp and hemoglobin concentration was recorded. These preliminary results may suggest a possible function of oxidative stress in the onset of clinical signs during the course of CME. MDPI 2022-02-08 /pmc/articles/PMC8868293/ /pubmed/35204210 http://dx.doi.org/10.3390/antiox11020328 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pugliese, Michela
Biondi, Vito
Merola, Giordana
Landi, Alessandra
Passantino, Annamaria
Oxidative Stress Evaluation in Dogs Affected with Canine Monocytic Ehrlichiosis
title Oxidative Stress Evaluation in Dogs Affected with Canine Monocytic Ehrlichiosis
title_full Oxidative Stress Evaluation in Dogs Affected with Canine Monocytic Ehrlichiosis
title_fullStr Oxidative Stress Evaluation in Dogs Affected with Canine Monocytic Ehrlichiosis
title_full_unstemmed Oxidative Stress Evaluation in Dogs Affected with Canine Monocytic Ehrlichiosis
title_short Oxidative Stress Evaluation in Dogs Affected with Canine Monocytic Ehrlichiosis
title_sort oxidative stress evaluation in dogs affected with canine monocytic ehrlichiosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868293/
https://www.ncbi.nlm.nih.gov/pubmed/35204210
http://dx.doi.org/10.3390/antiox11020328
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