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Bio-Availability, Anticancer Potential, and Chemical Data of Lycopene: An Overview and Technological Prospecting

The purpose of this review was to collect relevant chemical data about lycopene and its isomers, which can be extracted using different non-polar or polar aprotic solvents by SC-CO(2) or biosynthesis as a friendly technique. Lycopene and other carotenoids can be identified and quantified by UV–Vis a...

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Autores principales: Amorim, Adriany das Graças Nascimento, Vasconcelos, Andreanne Gomes, Souza, Jessica, Oliveira, Ana, Gullón, Beatriz, de Souza de Almeida Leite, José Roberto, Pintado, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868408/
https://www.ncbi.nlm.nih.gov/pubmed/35204241
http://dx.doi.org/10.3390/antiox11020360
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author Amorim, Adriany das Graças Nascimento
Vasconcelos, Andreanne Gomes
Souza, Jessica
Oliveira, Ana
Gullón, Beatriz
de Souza de Almeida Leite, José Roberto
Pintado, Manuela
author_facet Amorim, Adriany das Graças Nascimento
Vasconcelos, Andreanne Gomes
Souza, Jessica
Oliveira, Ana
Gullón, Beatriz
de Souza de Almeida Leite, José Roberto
Pintado, Manuela
author_sort Amorim, Adriany das Graças Nascimento
collection PubMed
description The purpose of this review was to collect relevant chemical data about lycopene and its isomers, which can be extracted using different non-polar or polar aprotic solvents by SC-CO(2) or biosynthesis as a friendly technique. Lycopene and other carotenoids can be identified and quantified by UV–Vis and HPLC using a C18 or C30 column, while their characterization is possible by UV–Vis, Fluorescence, FTIR, MS, NMR, and DSC assays. Among these techniques, the last four can compare lycopene isomers and identify cis or all-trans-lycopene. FTIR, MS, and NMR techniques are more suitable for the verification of the purity of lycopene extracts due to the signal complexity generated for each isomer, which enables identification by subtle differences. Additionally, some biological activities of lycopene isolated from red vegetables have already been confirmed, such as anti-inflammatory, antioxidant, and cytotoxic activity against cancer cells, probably by activating several pathways. The encapsulation of lycopene in nanoparticles demonstrated an improvement in oral delivery, and ex vivo assessments determined that these nanoparticles had better permeation and low cytotoxicity against human cells with enhanced permeation. These data suggest that lycopene has the potential to be applied in the food and pharmaceutical industries, as well as in cosmetic products.
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spelling pubmed-88684082022-02-25 Bio-Availability, Anticancer Potential, and Chemical Data of Lycopene: An Overview and Technological Prospecting Amorim, Adriany das Graças Nascimento Vasconcelos, Andreanne Gomes Souza, Jessica Oliveira, Ana Gullón, Beatriz de Souza de Almeida Leite, José Roberto Pintado, Manuela Antioxidants (Basel) Review The purpose of this review was to collect relevant chemical data about lycopene and its isomers, which can be extracted using different non-polar or polar aprotic solvents by SC-CO(2) or biosynthesis as a friendly technique. Lycopene and other carotenoids can be identified and quantified by UV–Vis and HPLC using a C18 or C30 column, while their characterization is possible by UV–Vis, Fluorescence, FTIR, MS, NMR, and DSC assays. Among these techniques, the last four can compare lycopene isomers and identify cis or all-trans-lycopene. FTIR, MS, and NMR techniques are more suitable for the verification of the purity of lycopene extracts due to the signal complexity generated for each isomer, which enables identification by subtle differences. Additionally, some biological activities of lycopene isolated from red vegetables have already been confirmed, such as anti-inflammatory, antioxidant, and cytotoxic activity against cancer cells, probably by activating several pathways. The encapsulation of lycopene in nanoparticles demonstrated an improvement in oral delivery, and ex vivo assessments determined that these nanoparticles had better permeation and low cytotoxicity against human cells with enhanced permeation. These data suggest that lycopene has the potential to be applied in the food and pharmaceutical industries, as well as in cosmetic products. MDPI 2022-02-11 /pmc/articles/PMC8868408/ /pubmed/35204241 http://dx.doi.org/10.3390/antiox11020360 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Amorim, Adriany das Graças Nascimento
Vasconcelos, Andreanne Gomes
Souza, Jessica
Oliveira, Ana
Gullón, Beatriz
de Souza de Almeida Leite, José Roberto
Pintado, Manuela
Bio-Availability, Anticancer Potential, and Chemical Data of Lycopene: An Overview and Technological Prospecting
title Bio-Availability, Anticancer Potential, and Chemical Data of Lycopene: An Overview and Technological Prospecting
title_full Bio-Availability, Anticancer Potential, and Chemical Data of Lycopene: An Overview and Technological Prospecting
title_fullStr Bio-Availability, Anticancer Potential, and Chemical Data of Lycopene: An Overview and Technological Prospecting
title_full_unstemmed Bio-Availability, Anticancer Potential, and Chemical Data of Lycopene: An Overview and Technological Prospecting
title_short Bio-Availability, Anticancer Potential, and Chemical Data of Lycopene: An Overview and Technological Prospecting
title_sort bio-availability, anticancer potential, and chemical data of lycopene: an overview and technological prospecting
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868408/
https://www.ncbi.nlm.nih.gov/pubmed/35204241
http://dx.doi.org/10.3390/antiox11020360
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