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Lipid Profile, Antioxidant and Antihypertensive Activity, and Computational Molecular Docking of Diatom Fatty Acids as ACE Inhibitors
Diatoms, as single cell eukaryotic microalgae, are rich sources of lipids, which have either beneficial or detrimental effects on the prevention and treatment of many diseases. Gas chromatography-mass spectrometry (GC-MS) identified diatom lipids with high levels of essential fatty acids (EFAs), esp...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868434/ https://www.ncbi.nlm.nih.gov/pubmed/35204069 http://dx.doi.org/10.3390/antiox11020186 |
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author | Pekkoh, Jeeraporn Phinyo, Kittiya Thurakit, Theera Lomakool, Sureeporn Duangjan, Kritsana Ruangrit, Khomsan Pumas, Chayakorn Jiranusornkul, Supat Yooin, Wipawadee Cheirsilp, Benjamas Pathom-aree, Wasu Srinuanpan, Sirasit |
author_facet | Pekkoh, Jeeraporn Phinyo, Kittiya Thurakit, Theera Lomakool, Sureeporn Duangjan, Kritsana Ruangrit, Khomsan Pumas, Chayakorn Jiranusornkul, Supat Yooin, Wipawadee Cheirsilp, Benjamas Pathom-aree, Wasu Srinuanpan, Sirasit |
author_sort | Pekkoh, Jeeraporn |
collection | PubMed |
description | Diatoms, as single cell eukaryotic microalgae, are rich sources of lipids, which have either beneficial or detrimental effects on the prevention and treatment of many diseases. Gas chromatography-mass spectrometry (GC-MS) identified diatom lipids with high levels of essential fatty acids (EFAs), especially polyunsaturated FAs (PUFAs) containing both omega-3 and omega-6. Nutritional values of FAs indicated possible applications in the pharmaceutical, nutraceutical, and functional food industries. Diatom FAs showed antioxidative potential on harmful radicals by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) scavenging, with high inhibition of the angiotensin-converting enzyme (ACE) that causes cardiovascular disease (CVD) and hypertension. A computational molecular docking simulation confirmed the inhibition mechanisms of FAs on ACE, with comparable levels of binding free energy to chemically synthesized ACE drugs. Findings suggested that diatom lipids showed potential for use as alternative ACE inhibitors or food supplement for CVD prevention. |
format | Online Article Text |
id | pubmed-8868434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88684342022-02-25 Lipid Profile, Antioxidant and Antihypertensive Activity, and Computational Molecular Docking of Diatom Fatty Acids as ACE Inhibitors Pekkoh, Jeeraporn Phinyo, Kittiya Thurakit, Theera Lomakool, Sureeporn Duangjan, Kritsana Ruangrit, Khomsan Pumas, Chayakorn Jiranusornkul, Supat Yooin, Wipawadee Cheirsilp, Benjamas Pathom-aree, Wasu Srinuanpan, Sirasit Antioxidants (Basel) Article Diatoms, as single cell eukaryotic microalgae, are rich sources of lipids, which have either beneficial or detrimental effects on the prevention and treatment of many diseases. Gas chromatography-mass spectrometry (GC-MS) identified diatom lipids with high levels of essential fatty acids (EFAs), especially polyunsaturated FAs (PUFAs) containing both omega-3 and omega-6. Nutritional values of FAs indicated possible applications in the pharmaceutical, nutraceutical, and functional food industries. Diatom FAs showed antioxidative potential on harmful radicals by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) scavenging, with high inhibition of the angiotensin-converting enzyme (ACE) that causes cardiovascular disease (CVD) and hypertension. A computational molecular docking simulation confirmed the inhibition mechanisms of FAs on ACE, with comparable levels of binding free energy to chemically synthesized ACE drugs. Findings suggested that diatom lipids showed potential for use as alternative ACE inhibitors or food supplement for CVD prevention. MDPI 2022-01-19 /pmc/articles/PMC8868434/ /pubmed/35204069 http://dx.doi.org/10.3390/antiox11020186 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pekkoh, Jeeraporn Phinyo, Kittiya Thurakit, Theera Lomakool, Sureeporn Duangjan, Kritsana Ruangrit, Khomsan Pumas, Chayakorn Jiranusornkul, Supat Yooin, Wipawadee Cheirsilp, Benjamas Pathom-aree, Wasu Srinuanpan, Sirasit Lipid Profile, Antioxidant and Antihypertensive Activity, and Computational Molecular Docking of Diatom Fatty Acids as ACE Inhibitors |
title | Lipid Profile, Antioxidant and Antihypertensive Activity, and Computational Molecular Docking of Diatom Fatty Acids as ACE Inhibitors |
title_full | Lipid Profile, Antioxidant and Antihypertensive Activity, and Computational Molecular Docking of Diatom Fatty Acids as ACE Inhibitors |
title_fullStr | Lipid Profile, Antioxidant and Antihypertensive Activity, and Computational Molecular Docking of Diatom Fatty Acids as ACE Inhibitors |
title_full_unstemmed | Lipid Profile, Antioxidant and Antihypertensive Activity, and Computational Molecular Docking of Diatom Fatty Acids as ACE Inhibitors |
title_short | Lipid Profile, Antioxidant and Antihypertensive Activity, and Computational Molecular Docking of Diatom Fatty Acids as ACE Inhibitors |
title_sort | lipid profile, antioxidant and antihypertensive activity, and computational molecular docking of diatom fatty acids as ace inhibitors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868434/ https://www.ncbi.nlm.nih.gov/pubmed/35204069 http://dx.doi.org/10.3390/antiox11020186 |
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