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Quercetin Improves Pulmonary Function and Prevents Emphysema Caused by Exposure to Cigarette Smoke in Male Mice

Chronic obstructive pulmonary disease (COPD) is the major cause of morbidity and mortality worldwide, and cigarette smoke is a key factor in the development of COPD. Thus, the development of effective therapies to prevent the advancement of COPD has become increasingly essential. We hypothesized tha...

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Autores principales: Araújo, Natália Pereira da Silva, de Matos, Natália Alves, Oliveira, Michel, de Souza, Ana Beatriz Farias, Castro, Thalles de Freitas, Machado-Júnior, Pedro Alves, de Souza, Débora Maria Soares, Talvani, André, Cangussú, Sílvia Dantas, de Menezes, Rodrigo Cunha Alvim, Bezerra, Frank Silva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868486/
https://www.ncbi.nlm.nih.gov/pubmed/35204064
http://dx.doi.org/10.3390/antiox11020181
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author Araújo, Natália Pereira da Silva
de Matos, Natália Alves
Oliveira, Michel
de Souza, Ana Beatriz Farias
Castro, Thalles de Freitas
Machado-Júnior, Pedro Alves
de Souza, Débora Maria Soares
Talvani, André
Cangussú, Sílvia Dantas
de Menezes, Rodrigo Cunha Alvim
Bezerra, Frank Silva
author_facet Araújo, Natália Pereira da Silva
de Matos, Natália Alves
Oliveira, Michel
de Souza, Ana Beatriz Farias
Castro, Thalles de Freitas
Machado-Júnior, Pedro Alves
de Souza, Débora Maria Soares
Talvani, André
Cangussú, Sílvia Dantas
de Menezes, Rodrigo Cunha Alvim
Bezerra, Frank Silva
author_sort Araújo, Natália Pereira da Silva
collection PubMed
description Chronic obstructive pulmonary disease (COPD) is the major cause of morbidity and mortality worldwide, and cigarette smoke is a key factor in the development of COPD. Thus, the development of effective therapies to prevent the advancement of COPD has become increasingly essential. We hypothesized that quercetin protects lungs in mice exposed to long-term cigarette smoke. Thirty-five C57BL/6 mice were exposed to cigarette smoke (12 cigarettes per day) for 60 days and pretreated with 10 mg/kg/day of quercetin via orogastric gavage. After the experimental protocol, the animals were euthanized and samples were collected for histopathological, antioxidant defense, oxidative stress and inflammatory analysis. The animals exposed to cigarette smoke showed an increase in respiratory rate and hematological parameters, cell influx into the airways, oxidative damage and inflammatory mediators, besides presenting with alterations in the pulmonary histoarchitecture. The animals receiving 10 mg/kg/day of quercetin that were exposed to cigarette smoke presented a reduction in cellular influx, less oxidative damage, reduction in cytokine levels, improvement in the histological pattern and improvement in pulmonary emphysema compared to the group that was only exposed to cigarette smoke. These results suggest that quercetin may be an agent in preventing pulmonary emphysema induced by cigarette smoke.
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spelling pubmed-88684862022-02-25 Quercetin Improves Pulmonary Function and Prevents Emphysema Caused by Exposure to Cigarette Smoke in Male Mice Araújo, Natália Pereira da Silva de Matos, Natália Alves Oliveira, Michel de Souza, Ana Beatriz Farias Castro, Thalles de Freitas Machado-Júnior, Pedro Alves de Souza, Débora Maria Soares Talvani, André Cangussú, Sílvia Dantas de Menezes, Rodrigo Cunha Alvim Bezerra, Frank Silva Antioxidants (Basel) Article Chronic obstructive pulmonary disease (COPD) is the major cause of morbidity and mortality worldwide, and cigarette smoke is a key factor in the development of COPD. Thus, the development of effective therapies to prevent the advancement of COPD has become increasingly essential. We hypothesized that quercetin protects lungs in mice exposed to long-term cigarette smoke. Thirty-five C57BL/6 mice were exposed to cigarette smoke (12 cigarettes per day) for 60 days and pretreated with 10 mg/kg/day of quercetin via orogastric gavage. After the experimental protocol, the animals were euthanized and samples were collected for histopathological, antioxidant defense, oxidative stress and inflammatory analysis. The animals exposed to cigarette smoke showed an increase in respiratory rate and hematological parameters, cell influx into the airways, oxidative damage and inflammatory mediators, besides presenting with alterations in the pulmonary histoarchitecture. The animals receiving 10 mg/kg/day of quercetin that were exposed to cigarette smoke presented a reduction in cellular influx, less oxidative damage, reduction in cytokine levels, improvement in the histological pattern and improvement in pulmonary emphysema compared to the group that was only exposed to cigarette smoke. These results suggest that quercetin may be an agent in preventing pulmonary emphysema induced by cigarette smoke. MDPI 2022-01-18 /pmc/articles/PMC8868486/ /pubmed/35204064 http://dx.doi.org/10.3390/antiox11020181 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Araújo, Natália Pereira da Silva
de Matos, Natália Alves
Oliveira, Michel
de Souza, Ana Beatriz Farias
Castro, Thalles de Freitas
Machado-Júnior, Pedro Alves
de Souza, Débora Maria Soares
Talvani, André
Cangussú, Sílvia Dantas
de Menezes, Rodrigo Cunha Alvim
Bezerra, Frank Silva
Quercetin Improves Pulmonary Function and Prevents Emphysema Caused by Exposure to Cigarette Smoke in Male Mice
title Quercetin Improves Pulmonary Function and Prevents Emphysema Caused by Exposure to Cigarette Smoke in Male Mice
title_full Quercetin Improves Pulmonary Function and Prevents Emphysema Caused by Exposure to Cigarette Smoke in Male Mice
title_fullStr Quercetin Improves Pulmonary Function and Prevents Emphysema Caused by Exposure to Cigarette Smoke in Male Mice
title_full_unstemmed Quercetin Improves Pulmonary Function and Prevents Emphysema Caused by Exposure to Cigarette Smoke in Male Mice
title_short Quercetin Improves Pulmonary Function and Prevents Emphysema Caused by Exposure to Cigarette Smoke in Male Mice
title_sort quercetin improves pulmonary function and prevents emphysema caused by exposure to cigarette smoke in male mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868486/
https://www.ncbi.nlm.nih.gov/pubmed/35204064
http://dx.doi.org/10.3390/antiox11020181
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