Cargando…

Nrf2/ARE Signaling Directly Regulates SOX9 to Potentially Alter Age-Dependent Cartilage Degeneration

Oxidative stress is implicated in osteoarthritis, and nuclear factor erythroid 2–related factor 2 (Nrf2)/antioxidant response element (ARE) pathway maintains redox homeostasis. We investigated whether Nrf2/ARE signaling controls SOX9. SOX9 expression in human C-28/I2 chondrocytes was measured by RT–...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kubo, Yusuke, Beckmann, Rainer, Fragoulis, Athanassios, Conrads, Claudius, Pavanram, Prathyusha, Nebelung, Sven, Wolf, Michael, Wruck, Christoph Jan, Jahr, Holger, Pufe, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868513/ https://www.ncbi.nlm.nih.gov/pubmed/35204144 http://dx.doi.org/10.3390/antiox11020263

Ejemplares similares

The Contribution of the Nrf2/ARE System to Mechanotransduction in Musculoskeletal and Periodontal Tissues
por: Fragoulis, Athanassios, et al.
Publicado: (2023)

Evaluation of Single-Impact-Induced Cartilage Degeneration by Optical Coherence Tomography
por: de Bont, Florence, et al.
Publicado: (2015)

Nuclear factor erythroid 2–related factor 2 (Nrf2) deficiency causes age-dependent progression of female osteoporosis
por: Kubo, Yusuke, et al.
Publicado: (2022)

Mechanical Forces Induce Changes in VEGF and VEGFR-1/sFlt-1 Expression in Human Chondrocytes
por: Beckmann, Rainer, et al.
Publicado: (2014)

Nrf2 Protects Against TWEAK-mediated Skeletal Muscle Wasting
por: Al-Sawaf, Othman, et al.
Publicado: (2014)

Physiological Mineralization during In Vitro Osteogenesis in a Biomimetic Spheroid Culture Model
por: Koblenzer, Maximilian, et al.
Publicado: (2022)

Bioreactor-Controlled Physoxia Regulates TGF-β Signaling to Alter Extracellular Matrix Synthesis by Human Chondrocytes
por: Jahr, Holger, et al.
Publicado: (2019)

Sulforaphane Exerts Beneficial Immunomodulatory Effects on Liver Tissue via a Nrf2 Pathway-Related Mechanism in a Murine Model of Hemorrhagic Shock and Resuscitation
por: Liang, Weiqiang, et al.
Publicado: (2022)

A Role for Nrf2 in Redox Signalling of the Invasive Extravillous Trophoblast in Severe Early Onset IUGR Associated with Preeclampsia
por: Kweider, Nisreen, et al.
Publicado: (2012)

Enoxaparin Prevents Steroid-Related Avascular Necrosis of the Femoral Head
por: Beckmann, Rainer, et al.
Publicado: (2014)

Corrigendum to “Enoxaparin Prevents Steroid-Related Avascular Necrosis of the Femoral Head”
por: Beckmann, Rainer, et al.
Publicado: (2015)

Nrf2 induces malignant transformation of hepatic progenitor cells by inducing β-catenin expression
por: Fragoulis, Athanassios, et al.
Publicado: (2022)

Platelet-Released Growth Factors Modulate the Secretion of Cytokines in Synoviocytes under Inflammatory Joint Disease
por: Tohidnezhad, Mersedeh, et al.
Publicado: (2017)

Abrasion arthroplasty increases mesenchymal stem cell content of postoperative joint effusions
por: Beckmann, Rainer, et al.
Publicado: (2015)

Detecting early stage osteoarthritis by optical coherence tomography?
por: Jahr, Holger, et al.
Publicado: (2015)

Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease
por: Fragoulis, Athanassios, et al.
Publicado: (2017)

Effects of Strontium-Doped β-Tricalcium Scaffold on Longitudinal Nuclear Factor-Kappa Beta and Vascular Endothelial Growth Factor Receptor-2 Promoter Activities during Healing in a Murine Critical-Size Bone Defect Model
por: Tohidnezhad, Mersedeh, et al.
Publicado: (2020)

Effect of platelet mediator concentrate (PMC) on Achilles tenocytes: an in vitro study
por: Arslan, Esra, et al.
Publicado: (2016)

HDACi and Nrf2: not from alpha to omega but from acetylation to OA
por: Jahr, Holger
Publicado: (2015)

Genetic Nrf2 Overactivation Inhibits the Deleterious Effects Induced by Hepatocyte-Specific c-met Deletion during the Progression of NASH
por: Ramadori, Pierluigi, et al.
Publicado: (2017)

Different Frequency of Cyclic Tensile Strain Relates to Anabolic/Catabolic Conditions Consistent with Immunohistochemical Staining Intensity in Tenocytes
por: Kubo, Yusuke, et al.
Publicado: (2020)

Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants
por: Fay, Jakob, et al.
Publicado: (2006)

Detection of Early-Stage Degeneration in Human Articular Cartilage by Multiparametric MR Imaging Mapping of Tissue Functionality
por: Nebelung, Sven, et al.
Publicado: (2019)

Sulforaphane has opposing effects on TNF-alpha stimulated and unstimulated synoviocytes
por: Fragoulis, Athanassios, et al.
Publicado: (2012)

DGEMRIC in the Assessment of Pre-Morphological Cartilage Degeneration in Rheumatic Disease: Rheumatoid Arthritis vs. Psoriatic Arthritis
por: Abrar, Daniel B., et al.
Publicado: (2021)

Longitudinal T2 Mapping and Texture Feature Analysis in the Detection and Monitoring of Experimental Post-Traumatic Cartilage Degeneration
por: Huppertz, Marc Sebastian, et al.
Publicado: (2021)

Physicochemical and Biomechanical Stimuli in Cell-Based Articular Cartilage Repair
por: Jahr, Holger, et al.
Publicado: (2015)

Nrf2 Is a Central Regulator of Metabolic Reprogramming of Myeloid-Derived Suppressor Cells in Steady State and Sepsis
por: Ohl, Kim, et al.
Publicado: (2018)

Inhibition of EZH2 ameliorates cartilage endplate degeneration and attenuates the progression of intervertebral disc degeneration via demethylation of Sox-9
por: Jiang, Chao, et al.
Publicado: (2019)

Detection of early cartilage degeneration in the tibiotalar joint using 3 T gagCEST imaging: a feasibility study
por: Abrar, Daniel B., et al.
Publicado: (2020)

A Novel Laser-Doppler Flowmetry Assisted Murine Model of Acute Hindlimb Ischemia-Reperfusion for Free Flap Research
por: Sönmez, Tolga Taha, et al.
Publicado: (2013)

Astrocytic Nrf2 expression protects spinal cord from oxidative stress following spinal cord injury in a male mouse model
por: Zhao, Weiyi, et al.
Publicado: (2022)

Nutrition and degeneration of articular cartilage
por: Wang, Yuze, et al.
Publicado: (2012)

Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate
por: Smits, Patrick, et al.
Publicado: (2004)

Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation
por: Kim, Sukyeong, et al.
Publicado: (2019)

Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration
por: Barrionuevo, Francisco J, et al.
Publicado: (2016)

Reference Gene Selection for Gene Expression Analyses in Mouse Models of Acute Lung Injury
por: Fragoulis, Athanassios, et al.
Publicado: (2021)

Fast, Accurate, and Robust T2 Mapping of Articular Cartilage by Neural Networks
por: Müller-Franzes, Gustav, et al.
Publicado: (2022)

The role of bone mineral density and cartilage volume to predict knee cartilage degeneration
por: Ciliberti, Federica Kiyomi, et al.
Publicado: (2022)

Degeneration of Acetabular Articular Cartilage to Bipolar Hemiarthroplasty
por: Moon, Kyoung Ho, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_3bsjbjkmtm7agoh74q6ae5dos2