Levels of Plasma Coenzyme Q(10) Are Associated with Physical Capacity and Cardiovascular Risk in the Elderly

Coenzyme Q(10) (CoQ(10)) is an essential factor for mitochondrial activity and antioxidant protection of cells, tissues and plasma lipoproteins. Its deficiency has been associated with aging progression in animals and humans. To determine if CoQ(10) levels in plasma can be associated with frailty in elderly people (aged > 65), we studied the relationship of CoQ(10) levels in blood with other parameters in plasma and with the physical activity and capacity in aged people. Our results indicate that high CoQ(10) levels are directly associated with lower cardiovascular risk measured by the quotient total cholesterol/HDL cholesterol. Furthermore, high CoQ(10) levels were found in people showing higher physical activity, stronger muscle capacity. CoQ(10) also showed a strong inverse relationship with sedentarism and the up and go test, which is considered to be a frailty index. Interestingly, we found gender differences, indicating stronger correlations in women than in men. The importance of the maintenance of CoQ(10) levels in elderly people to avoid sarcopenia and frailty in elderly people is discussed.