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The Neuropsychiatric Changes After COVID-19 Quarantine in Patients With Cognitive Impairment and Their Caregivers in Chongqing, China: A Cohort Study

BACKGROUND: The follow-up study on neuropsychiatric changes after the lifting of coronavirus disease 2019 (COVID-19) quarantine in patients with cognitive impairment and their caregivers is still lacking, and relative information is needed to formulate more comprehensive healthcare prevention measur...

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Autores principales: Yuan, Shiyun, Zhang, Wenbo, Yao, Qiang, Lü, Wenqi, Yu, Wuhan, Zhong, Fuxin, Wang, Yan, Xing, Dianxia, Wang, Xiaoqin, Song, Jiaqi, Huang, Hong, Chen, Chenxi, Liu, Junjin, Yu, Weihua, Lü, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868570/
https://www.ncbi.nlm.nih.gov/pubmed/35221981
http://dx.doi.org/10.3389/fnagi.2021.762907
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author Yuan, Shiyun
Zhang, Wenbo
Yao, Qiang
Lü, Wenqi
Yu, Wuhan
Zhong, Fuxin
Wang, Yan
Xing, Dianxia
Wang, Xiaoqin
Song, Jiaqi
Huang, Hong
Chen, Chenxi
Liu, Junjin
Yu, Weihua
Lü, Yang
author_facet Yuan, Shiyun
Zhang, Wenbo
Yao, Qiang
Lü, Wenqi
Yu, Wuhan
Zhong, Fuxin
Wang, Yan
Xing, Dianxia
Wang, Xiaoqin
Song, Jiaqi
Huang, Hong
Chen, Chenxi
Liu, Junjin
Yu, Weihua
Lü, Yang
author_sort Yuan, Shiyun
collection PubMed
description BACKGROUND: The follow-up study on neuropsychiatric changes after the lifting of coronavirus disease 2019 (COVID-19) quarantine in patients with cognitive impairment and their caregivers is still lacking, and relative information is needed to formulate more comprehensive healthcare prevention measures worldwide. AIMS: To provide data on the changes in neuropsychiatric performance after the lifting of COVID-19 quarantine in patients with cognitive disorders and their caregivers. METHODS: Two surveys in Chongqing, China were conducted via telephonic interview with 531 patients and their caregivers. The baseline survey was performed from February 11 to 23, 2020, and the follow-up was from October 24 to November 9, 2020. The data of neuropsychiatric symptoms (NPSs), sleep, nutrition, and chronic diseases of patients, as well as the burden of care, anxiety, and depression of caregivers were evaluated. RESULTS: Significant alleviation of NPSs after the lifting of COVID-19 quarantine was observed in patients with mild cognitive impairment (MCI) and dementia (both P < 0.05). Compared with baseline, the prevalence for NPSs of all participants dropped from 57.94 to 38.82%. Among NPS subdomains, apathy displayed the biggest decline at follow-up by 10.72%, followed by nighttime behavior by 8.65%. Mixed effect generalized estimation equation analysis showed significant amelioration in hallucination, depression, apathy, irritability, aberrant motor behavior, and nighttime behavior (all P < 0.05), with the most prominent changes in nighttime behavior and apathy. Among the patients with unsatisfactory control of chronic disease, the medication adherence rate dropped by approximately 30% after the lifting of quarantine. More importantly, around 13% increase of care burden was observed among the caregivers at follow-up, with both depression and anxiety rising by nearly 4%. CONCLUSION: The prolonged quarantine may exacerbate NPS in patients with memory disorders, while the care burden and mental stability of the caregivers after the pandemic should also be concerned.
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spelling pubmed-88685702022-02-25 The Neuropsychiatric Changes After COVID-19 Quarantine in Patients With Cognitive Impairment and Their Caregivers in Chongqing, China: A Cohort Study Yuan, Shiyun Zhang, Wenbo Yao, Qiang Lü, Wenqi Yu, Wuhan Zhong, Fuxin Wang, Yan Xing, Dianxia Wang, Xiaoqin Song, Jiaqi Huang, Hong Chen, Chenxi Liu, Junjin Yu, Weihua Lü, Yang Front Aging Neurosci Aging Neuroscience BACKGROUND: The follow-up study on neuropsychiatric changes after the lifting of coronavirus disease 2019 (COVID-19) quarantine in patients with cognitive impairment and their caregivers is still lacking, and relative information is needed to formulate more comprehensive healthcare prevention measures worldwide. AIMS: To provide data on the changes in neuropsychiatric performance after the lifting of COVID-19 quarantine in patients with cognitive disorders and their caregivers. METHODS: Two surveys in Chongqing, China were conducted via telephonic interview with 531 patients and their caregivers. The baseline survey was performed from February 11 to 23, 2020, and the follow-up was from October 24 to November 9, 2020. The data of neuropsychiatric symptoms (NPSs), sleep, nutrition, and chronic diseases of patients, as well as the burden of care, anxiety, and depression of caregivers were evaluated. RESULTS: Significant alleviation of NPSs after the lifting of COVID-19 quarantine was observed in patients with mild cognitive impairment (MCI) and dementia (both P < 0.05). Compared with baseline, the prevalence for NPSs of all participants dropped from 57.94 to 38.82%. Among NPS subdomains, apathy displayed the biggest decline at follow-up by 10.72%, followed by nighttime behavior by 8.65%. Mixed effect generalized estimation equation analysis showed significant amelioration in hallucination, depression, apathy, irritability, aberrant motor behavior, and nighttime behavior (all P < 0.05), with the most prominent changes in nighttime behavior and apathy. Among the patients with unsatisfactory control of chronic disease, the medication adherence rate dropped by approximately 30% after the lifting of quarantine. More importantly, around 13% increase of care burden was observed among the caregivers at follow-up, with both depression and anxiety rising by nearly 4%. CONCLUSION: The prolonged quarantine may exacerbate NPS in patients with memory disorders, while the care burden and mental stability of the caregivers after the pandemic should also be concerned. Frontiers Media S.A. 2022-02-10 /pmc/articles/PMC8868570/ /pubmed/35221981 http://dx.doi.org/10.3389/fnagi.2021.762907 Text en Copyright © 2022 Yuan, Zhang, Yao, Lü, Yu, Zhong, Wang, Xing, Wang, Song, Huang, Chen, Liu, Yu and Lü. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Yuan, Shiyun
Zhang, Wenbo
Yao, Qiang
Lü, Wenqi
Yu, Wuhan
Zhong, Fuxin
Wang, Yan
Xing, Dianxia
Wang, Xiaoqin
Song, Jiaqi
Huang, Hong
Chen, Chenxi
Liu, Junjin
Yu, Weihua
Lü, Yang
The Neuropsychiatric Changes After COVID-19 Quarantine in Patients With Cognitive Impairment and Their Caregivers in Chongqing, China: A Cohort Study
title The Neuropsychiatric Changes After COVID-19 Quarantine in Patients With Cognitive Impairment and Their Caregivers in Chongqing, China: A Cohort Study
title_full The Neuropsychiatric Changes After COVID-19 Quarantine in Patients With Cognitive Impairment and Their Caregivers in Chongqing, China: A Cohort Study
title_fullStr The Neuropsychiatric Changes After COVID-19 Quarantine in Patients With Cognitive Impairment and Their Caregivers in Chongqing, China: A Cohort Study
title_full_unstemmed The Neuropsychiatric Changes After COVID-19 Quarantine in Patients With Cognitive Impairment and Their Caregivers in Chongqing, China: A Cohort Study
title_short The Neuropsychiatric Changes After COVID-19 Quarantine in Patients With Cognitive Impairment and Their Caregivers in Chongqing, China: A Cohort Study
title_sort neuropsychiatric changes after covid-19 quarantine in patients with cognitive impairment and their caregivers in chongqing, china: a cohort study
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868570/
https://www.ncbi.nlm.nih.gov/pubmed/35221981
http://dx.doi.org/10.3389/fnagi.2021.762907
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