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Chemical Composition and Antioxidant Activity of Ammi visnaga L. Essential Oil

The present study evaluated the chemical composition and the in vitro and in vivo antioxidant potential of Ammi visnaga L. essential oil to provide a scientific basis for the use of this plant in the traditional pharmacopoeia. Gas chromatography-mass spectrometry was used to identify the volatile co...

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Autores principales: Kamal, Fatima Zahra, Stanciu, Gabriela Dumitrita, Lefter, Radu, Cotea, Valeriu V., Niculaua, Marius, Ababei, Daniela Carmen, Ciobica, Alin, Ech-Chahad, Abdellah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868941/
https://www.ncbi.nlm.nih.gov/pubmed/35204230
http://dx.doi.org/10.3390/antiox11020347
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author Kamal, Fatima Zahra
Stanciu, Gabriela Dumitrita
Lefter, Radu
Cotea, Valeriu V.
Niculaua, Marius
Ababei, Daniela Carmen
Ciobica, Alin
Ech-Chahad, Abdellah
author_facet Kamal, Fatima Zahra
Stanciu, Gabriela Dumitrita
Lefter, Radu
Cotea, Valeriu V.
Niculaua, Marius
Ababei, Daniela Carmen
Ciobica, Alin
Ech-Chahad, Abdellah
author_sort Kamal, Fatima Zahra
collection PubMed
description The present study evaluated the chemical composition and the in vitro and in vivo antioxidant potential of Ammi visnaga L. essential oil to provide a scientific basis for the use of this plant in the traditional pharmacopoeia. Gas chromatography-mass spectrometry was used to identify the volatile constituents present of the oil. The in vitro antioxidant capacity was evaluated by the DPPH and the reducing power assays. For the in vivo tests, oral administration of Ammi visnaga L. oil (600 and 1200 mg/kg body weight) was performed in Swiss albino mice treated with acetaminophen (400 mg/kg). The toxic effect of acetaminophen and the action of the essential oil were measured by determining the levels of lipid peroxidation and antioxidant enzymes in liver and kidneys homogenates. The major components identified were butanoic acid, 2-methyl-, pentyl ester, (Z)-β-ocimene, D-limonene, linalool, pulegone and lavandulyl-butyrate. The in vitro DPPH and reducing power assays showed moderate to low free radical scavenging activity and the antioxidant power was positively correlated with the polyphenols’ concentration. In vivo, the Ammi visnaga L. essential oil showed a high antioxidant capacity at both concentrations (600 and 1200 mg/kg), effectively increasing the levels of reduced glutathione, superoxide dismutase, and catalase and significantly reducing the lipid peroxidation. The results obtained from this study suggest that Ammi visnaga L. could represent a source of molecules with antioxidant potential in the prevention of free radical-related diseases.
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spelling pubmed-88689412022-02-25 Chemical Composition and Antioxidant Activity of Ammi visnaga L. Essential Oil Kamal, Fatima Zahra Stanciu, Gabriela Dumitrita Lefter, Radu Cotea, Valeriu V. Niculaua, Marius Ababei, Daniela Carmen Ciobica, Alin Ech-Chahad, Abdellah Antioxidants (Basel) Article The present study evaluated the chemical composition and the in vitro and in vivo antioxidant potential of Ammi visnaga L. essential oil to provide a scientific basis for the use of this plant in the traditional pharmacopoeia. Gas chromatography-mass spectrometry was used to identify the volatile constituents present of the oil. The in vitro antioxidant capacity was evaluated by the DPPH and the reducing power assays. For the in vivo tests, oral administration of Ammi visnaga L. oil (600 and 1200 mg/kg body weight) was performed in Swiss albino mice treated with acetaminophen (400 mg/kg). The toxic effect of acetaminophen and the action of the essential oil were measured by determining the levels of lipid peroxidation and antioxidant enzymes in liver and kidneys homogenates. The major components identified were butanoic acid, 2-methyl-, pentyl ester, (Z)-β-ocimene, D-limonene, linalool, pulegone and lavandulyl-butyrate. The in vitro DPPH and reducing power assays showed moderate to low free radical scavenging activity and the antioxidant power was positively correlated with the polyphenols’ concentration. In vivo, the Ammi visnaga L. essential oil showed a high antioxidant capacity at both concentrations (600 and 1200 mg/kg), effectively increasing the levels of reduced glutathione, superoxide dismutase, and catalase and significantly reducing the lipid peroxidation. The results obtained from this study suggest that Ammi visnaga L. could represent a source of molecules with antioxidant potential in the prevention of free radical-related diseases. MDPI 2022-02-10 /pmc/articles/PMC8868941/ /pubmed/35204230 http://dx.doi.org/10.3390/antiox11020347 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kamal, Fatima Zahra
Stanciu, Gabriela Dumitrita
Lefter, Radu
Cotea, Valeriu V.
Niculaua, Marius
Ababei, Daniela Carmen
Ciobica, Alin
Ech-Chahad, Abdellah
Chemical Composition and Antioxidant Activity of Ammi visnaga L. Essential Oil
title Chemical Composition and Antioxidant Activity of Ammi visnaga L. Essential Oil
title_full Chemical Composition and Antioxidant Activity of Ammi visnaga L. Essential Oil
title_fullStr Chemical Composition and Antioxidant Activity of Ammi visnaga L. Essential Oil
title_full_unstemmed Chemical Composition and Antioxidant Activity of Ammi visnaga L. Essential Oil
title_short Chemical Composition and Antioxidant Activity of Ammi visnaga L. Essential Oil
title_sort chemical composition and antioxidant activity of ammi visnaga l. essential oil
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868941/
https://www.ncbi.nlm.nih.gov/pubmed/35204230
http://dx.doi.org/10.3390/antiox11020347
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